Cryo-EM structure of apo human SLC19A3 in outward-open state
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8s4u
Q-score: 0.575
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Slc19a3:nb3.4-apo (75 kDa, Complex)
- Slc19a3 (Complex from Homo sapiens)
- Nb3.4-apo (Complex from Lama glama)
- Nanobody 3.4 (15 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of thiamine-bound human SLC19A3 in outward-open state
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8s5u
Q-score: 0.554
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium (265 Da, Ligand)
- Slc19a3:nb3.4:thiamine (Complex from Homo sapiens)
- Nb3.4 (15 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8s5w
Q-score: 0.57
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Nb3.7 (15 kDa, Protein from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- Slc19a3:nb3.7:fedratinib (Complex from Homo sapiens)
- Nb3.7 (Complex from Lama glama)
- N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide (524 Da, Ligand)
Cryo-EM structure of hydroxychloroquine-bound human SLC19A3 in inward-open state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8s5z
Q-score: 0.556
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Hydroxychloroquine (335 Da, Ligand)
- Nb3.3 (Complex from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- Nb3.3 (15 kDa, Protein from Lama glama)
- Slc19a3:nb3.7:hydroxychloroquine (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8s61
Q-score: 0.527
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Slc19a3 (Complex from Homo sapiens)
- 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium (265 Da, Ligand)
- Slc19a3:nb3.7:thiamine (Complex from Homo sapiens)
- Nb3.7 (13 kDa, Protein from Lama glama)
- Nb3.7 (Complex from Lama glama)
- Thiamine transporter 2 (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of amprolium-bound human SLC19A3 in inward-open state
Resolution: 3.75 Å
EM Method: Single-particle
Fitted PDBs: 8s62
Q-score: 0.46
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Slc19a3:nb3.7:amprolium (Complex from Homo sapiens)
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Nb3.7 (15 kDa, Protein from Lama glama)
- Amprolium (243 Da, Ligand)
- Slc19a3 (Complex from Homo sapiens)
- Nb3.7 (Complex from Lama glama)
Cryo-EM structure of apo human SLC19A3 in inward-open state
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 9g5k
Q-score: 0.579
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Slc19a3:nb3.3-apo (Complex from Homo sapiens)
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Nb3.3 (Complex from Lama glama)
- Nanobody 3.3 (15 kDa, Protein from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
structure of the GLMP/MFSD1 complex
Jungnickel KEJ, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa Lopez D, Saftig P, Mehdipour AR, Abu-Remaileh M, Gasnier B, Low C, Damme M
Nat Cell Biol (2024) 26 pp. 1047-1061 [ DOI: doi:10.1038/s41556-024-01436-5 Pubmed: 38839979 ]
- Glmp-mfsd1 (Complex from Mus musculus)
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 8r8q
Q-score: 0.411
Jungnickel KEJ, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa Lopez D, Saftig P, Mehdipour AR, Abu-Remaileh M, Gasnier B, Low C, Damme M
Nat Cell Biol (2024) 26 pp. 1047-1061 [ DOI: doi:10.1038/s41556-024-01436-5 Pubmed: 38839979 ]
- Glmp-mfsd1 (Complex from Mus musculus)
- Glycosylated lysosomal membrane protein (43 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Major facilitator superfamily domain-containing protein 1 (55 kDa, Protein from Mus musculus)
PHT1 in the outward facing conformation, bound to Sb27
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8cni
Q-score: 0.492
Custodio TF, Killer M, Yu D, Puente V, Teufel DP, Pautsch A, Schnapp G, Grundl M, Kosinski J, Low C
Nat Commun (2023) 14 pp. 5696-5696 [ Pubmed: 37709742 DOI: doi:10.1038/s41467-023-41420-5 ]
- Sybody 27 (Complex from Escherichia coli)
- Solute carrier family 15 member 4 (63 kDa, Protein from Gallus gallus)
- Solute carrier family 15 member 4 (Complex from Homo sapiens)
- Sybody 27 (13 kDa, Protein from Escherichia coli)
- Pht1-sb27 (Complex)