Cryo-EM structure of apo human SLC19A3 in outward-open state
Resolution: 3.09 Å
EM Method: Single-particle
Fitted PDBs: 8s4u
Q-score: 0.575
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Slc19a3:nb3.4-apo (75 kDa, Complex)
- Slc19a3 (Complex from Homo sapiens)
- Nb3.4-apo (Complex from Lama glama)
- Nanobody 3.4 (15 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of thiamine-bound human SLC19A3 in outward-open state
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 8s5u
Q-score: 0.554
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium (265 Da, Ligand)
- Slc19a3:nb3.4:thiamine (Complex from Homo sapiens)
- Nb3.4 (15 kDa, Protein from Lama glama)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of fedratinib-bound human SLC19A3 in inward-open state
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8s5w
Q-score: 0.57
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Nb3.7 (15 kDa, Protein from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- Slc19a3:nb3.7:fedratinib (Complex from Homo sapiens)
- Nb3.7 (Complex from Lama glama)
- N-tert-butyl-3-{[5-methyl-2-({4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}amino)pyrimidin-4-yl]amino}benzenesulfonamide (524 Da, Ligand)
Cryo-EM structure of hydroxychloroquine-bound human SLC19A3 in inward-open state
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8s5z
Q-score: 0.556
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Hydroxychloroquine (335 Da, Ligand)
- Nb3.3 (Complex from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- Nb3.3 (15 kDa, Protein from Lama glama)
- Slc19a3:nb3.7:hydroxychloroquine (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of thiamine-bound human SLC19A3 in inward-open state
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8s61
Q-score: 0.527
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Slc19a3 (Complex from Homo sapiens)
- 3-(4-amino-2-methyl-pyrimidin-5-ylmethyl)-5-(2-hydroxy-ethyl)-4-methyl-thiazol-3-ium (265 Da, Ligand)
- Slc19a3:nb3.7:thiamine (Complex from Homo sapiens)
- Nb3.7 (13 kDa, Protein from Lama glama)
- Nb3.7 (Complex from Lama glama)
- Thiamine transporter 2 (50 kDa, Protein from Homo sapiens)
Cryo-EM structure of apo human SLC19A3 in inward-open state
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 9g5k
Q-score: 0.579
Gabriel F, Spriestersbach L, Fuhrmann A, Jungnickel KEJ, Mostafavi S, Pardon E, Steyaert J, Low C
Nat Commun (2024) 15 pp. 8542-8542 [ Pubmed: 39358356 DOI: doi:10.1038/s41467-024-52872-8 ]
- Slc19a3:nb3.3-apo (Complex from Homo sapiens)
- Thiamine transporter 2 (59 kDa, Protein from Homo sapiens)
- Nb3.3 (Complex from Lama glama)
- Nanobody 3.3 (15 kDa, Protein from Lama glama)
- Slc19a3 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 8r8q
Q-score: 0.411
Jungnickel KEJ, Guelle O, Iguchi M, Dong W, Kotov V, Gabriel F, Debacker C, Dairou J, McCort-Tranchepain I, Laqtom NN, Chan SH, Ejima A, Sato K, Massa Lopez D, Saftig P, Mehdipour AR, Abu-Remaileh M, Gasnier B, Low C, Damme M
Nat Cell Biol (2024) 26 pp. 1047-1061 [ DOI: doi:10.1038/s41556-024-01436-5 Pubmed: 38839979 ]
- Glmp-mfsd1 (Complex from Mus musculus)
- Glycosylated lysosomal membrane protein (43 kDa, Protein from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Major facilitator superfamily domain-containing protein 1 (55 kDa, Protein from Mus musculus)
Cryo-EM structure of the SARS-CoV-2 spike protein bound to neutralizing sybodies (Sb23)
Resolution: 3.06 Å
EM Method: Single-particle
Fitted PDBs: 7a25
Q-score: 0.386
Custodio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hallberg BM, Low C
Nat Commun (2020) 11 pp. 5588-5588 [ DOI: doi:10.1038/s41467-020-19204-y Pubmed: 33149112 ]
- Spike glycoprotein (126 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein in 1-up conformation bound by 3 neutralising sybodies (sb23) (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralising sybody (sb23) (Complex from synthetic construct)
- Sybody 23 (12 kDa, Protein from synthetic construct)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 7a29
Q-score: 0.398
Custodio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hallberg BM, Low C
Nat Commun (2020) 11 pp. 5588-5588 [ DOI: doi:10.1038/s41467-020-19204-y Pubmed: 33149112 ]
- Sars-cov-2 spike glycoprotein in 1-up conformation bound by 3 neutralising sybodies (sb23) (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Neutralising sybody (sb23) (12 kDa, Protein from synthetic construct)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralising sybody (sb23) (Complex from synthetic construct)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)