Cryo-EM structure of human ZnT1, in the absence of zinc, determined in outward-facing conformation
Resolution: 3.26 Å
EM Method: Single-particle
Fitted PDBs: 8zsb
Q-score: 0.487
Li Y, Ma J, Wang R, Luo Y, Zheng S, Wang X
Cell Metab. (2024) 36 pp. 2118- [ Pubmed: 39111308 DOI: doi:10.1016/j.cmet.2024.07.009 ]
- Cryo-em structure of the znt1 in the apo state (Complex from Homo sapiens)
- Proton-coupled zinc antiporter slc30a1 (55 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of human ZnT1, in the presence of zinc, determined in outward-facing conformation
Li Y, Ma J, Wang R, Luo Y, Zheng S, Wang X
Cell Metab. (2024) 36 pp. 2118- [ Pubmed: 39111308 DOI: doi:10.1016/j.cmet.2024.07.009 ]
- Proton-coupled zinc antiporter slc30a1 (55 kDa, Protein from Homo sapiens)
- Cryo-em structure of the znt1 in the presence of zinc (Complex from Homo sapiens)
- Zinc ion (65 Da, Ligand)
Structure of PfNT1(Y190A)-GFP in complex with GSK4
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 7ydq
Q-score: 0.31
Structure of PfENT1(Y190A) in complex with nanobody 19
Resolution: 3.64 Å
EM Method: Single-particle
Fitted PDBs: 7wn0
Q-score: 0.489
Wang C, Yu L, Zhang J, Zhou Y, Sun B, Xiao Q, Zhang M, Liu H, Li J, Li J, Luo Y, Xu J, Lian Z, Lin J, Wang X, Zhang P, Guo L, Ren R, Deng D
Nat Commun (2023) 14 pp. 1727-1727 [ DOI: doi:10.1038/s41467-023-37411-1 Pubmed: 36977719 ]
- Pfent1(y190a) in complex with nanobody 19 (Complex from Plasmodium falciparum)
- Equilibrative nucleoside/nucleobase transporter (47 kDa, Protein from Plasmodium falciparum)
- Nanobody19 (13 kDa, Protein from Vicugna pacos)
- Nanobody 19 (Complex)
- Pfent1 (Complex from Vicugna pacos)
Structure of PfNT1(Y190A) in complex with nanobody 48 and inosine
Resolution: 3.11 Å
EM Method: Single-particle
Fitted PDBs: 7wn1
Q-score: 0.545
Wang C, Yu L, Zhang J, Zhou Y, Sun B, Xiao Q, Zhang M, Liu H, Li J, Li J, Luo Y, Xu J, Lian Z, Lin J, Wang X, Zhang P, Guo L, Ren R, Deng D
Nat Commun (2023) 14 pp. 1727-1727 [ DOI: doi:10.1038/s41467-023-37411-1 Pubmed: 36977719 ]
- Inosine (268 Da, Ligand)
- Nanobody 48 (Complex)
- Equilibrative nucleoside/nucleobase transporter (47 kDa, Protein from Plasmodium falciparum)
- Structure of pfnt1(y190a) in complex with nanobody 48 and inosine (Complex from Plasmodium falciparum)
- Nanobody48 (13 kDa, Protein from Vicugna pacos)
- Pfnt1 (Complex from Vicugna pacos)
Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew2
Q-score: 0.441
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- (2~{s})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol (387 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ew3
Q-score: 0.51
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- (2s,3r,4e)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate (379 Da, Ligand)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7ew4
Q-score: 0.457
Zhao C, Cheng L, Wang W, Wang H, Luo Y, Feng Y, Wang X, Fu H, Cai Y, Yang S, Fu P, Yan W, Shao Z
Cell Res (2022) 32 pp. 218-221 [ DOI: doi:10.1038/s41422-021-00567-w Pubmed: 34545189 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 (46 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Homo sapiens)
- N,n-dicyclohexyl-5-cyclopropyl-1,2-oxazole-3-carboxamide (316 Da, Ligand)
- Palmitic acid (256 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Sphingosine 1-phosphate receptor 3 complexed with gi protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)