Cryo-EM structure of E. coli RNAP sigma32 complex
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8hkc
Q-score: 0.582
Lu Q, Chen T, Wang J, Wang F, Ye W, Ma L, Wu S
Biomolecules (2023) 13 [ DOI: doi:10.3390/biom13050738 Pubmed: 37238608 ]
- Dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Zinc ion (65 Da, Ligand)
- Rna polymerase sigma factor rpoh (32 kDa, Protein from Escherichia coli K-12)
- Cryo-em structure of e. coli rnap sigma32 complex (Complex from Escherichia coli K-12)
- Magnesium ion (24 Da, Ligand)
- Dna-directed rna polymerase subunit beta (151 kDa, Protein from Escherichia coli K-12)
- Dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Dna-directed rna polymerase subunit alpha (36 kDa, Protein from Escherichia coli K-12)
- Dna-directed rna polymerase subunit beta' (157 kDa, Protein from Escherichia coli K-12)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Nb35 (15 kDa, Protein from Lama glama)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- Gs complex (Complex from Homo sapiens)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Gs complex (Complex from Homo sapiens)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wks
Q-score: 0.527
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7wkw
Q-score: 0.448
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xxb
Q-score: 0.526
Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J
Nature (2022) 609 pp. 616-621 [ DOI: doi:10.1038/s41586-022-05142-w Pubmed: 35917926 ]
- Auxin efflux carrier component 3 (73 kDa, Protein from Arabidopsis thaliana)
- Iaa-bound state atpin3(atpin3-iaa) (Complex from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Active human TGR5 complex with a synthetic agonist 23H
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7bw0
Q-score: 0.382
Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R
Signal Transduct Target Ther (2020) 5 pp. 142-142 [ DOI: doi:10.1038/s41392-020-00262-z Pubmed: 32747649 ]
- 4 (Cellular component from Bos taurus)
- 3 (Cellular component from Rattus norvegicus)
- Nanobody nb35 (17 kDa, Protein from Vicugna pacos)
- 2 (Cellular component from Homo sapiens)
- Soluble cytochrome b562,g-protein coupled bile acid receptor 1 (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Tgr5+gs (Complex)
- 5 (Cellular component from Vicugna pacos)