Cryo-EM structure of E. coli RNAP sigma32 complex
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8hkc
Q-score: 0.582
Lu Q, Chen T, Wang J, Wang F, Ye W, Ma L, Wu S
Biomolecules (2023) 13 [ DOI: doi:10.3390/biom13050738 Pubmed: 37238608 ]
- Dna-directed rna polymerase subunit alpha (36 kDa, Protein from Escherichia coli K-12)
- Dna-directed rna polymerase subunit beta (151 kDa, Protein from Escherichia coli K-12)
- Dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Rna polymerase sigma factor rpoh (32 kDa, Protein from Escherichia coli K-12)
- Magnesium ion (24 Da, Ligand)
- Cryo-em structure of e. coli rnap sigma32 complex (Complex from Escherichia coli K-12)
- Dna (54-mer) (16 kDa, DNA from Escherichia coli)
- Dna-directed rna polymerase subunit beta' (157 kDa, Protein from Escherichia coli K-12)
- Zinc ion (65 Da, Ligand)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist MBX-2982
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 7wcm
Q-score: 0.652
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- 2-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]-4-[[4-(1,2,3,4-tetrazol-1-yl)phenoxy]methyl]-1,3-thiazole (448 Da, Ligand)
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Gpr119-gs signaling complexes with mbx-2982 (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Nb35 (Complex from Lama glama)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Gs complex (Complex from Homo sapiens)
Cryo-EM structure of GPR119-Gs Complex with small molecule agonist AR231453
Resolution: 2.87 Å
EM Method: Single-particle
Fitted PDBs: 7wcn
Q-score: 0.576
Qian Y, Wang J, Yang L, Liu Y, Wang L, Liu W, Lin Y, Yang H, Ma L, Ye S, Wu S, Qiao A
Nat Commun (2022) 13 pp. 7033-7033 [ Pubmed: 36396650 DOI: doi:10.1038/s41467-022-34696-6 ]
- Nb35 (15 kDa, Protein from Lama glama)
- Glucose-dependent insulinotropic receptor (36 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Cryo-em structure of gpr119-gs complex with small molecule agonist ar231453 (Complex)
- Nb35 (Complex from Lama glama)
- N-(2-fluoranyl-4-methylsulfonyl-phenyl)-5-nitro-6-[4-(3-propan-2-yl-1,2,4-oxadiazol-5-yl)piperidin-1-yl]pyrimidin-4-amine (505 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (45 kDa, Protein from Homo sapiens)
- Gs complex (Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7wks
Q-score: 0.527
Resolution: 2.62 Å
EM Method: Single-particle
Fitted PDBs: 7wkw
Q-score: 0.448
Resolution: 2.93 Å
EM Method: Single-particle
Fitted PDBs: 7xxb
Q-score: 0.526
Su N, Zhu A, Tao X, Ding ZJ, Chang S, Ye F, Zhang Y, Zhao C, Chen Q, Wang J, Zhou CY, Guo Y, Jiao S, Zhang S, Wen H, Ma L, Ye S, Zheng SJ, Yang F, Wu S, Guo J
Nature (2022) 609 pp. 616-621 [ Pubmed: 35917926 DOI: doi:10.1038/s41586-022-05142-w ]
- Iaa-bound state atpin3(atpin3-iaa) (Complex from Arabidopsis thaliana)
- Auxin efflux carrier component 3 (73 kDa, Protein from Arabidopsis thaliana)
- 1h-indol-3-ylacetic acid (175 Da, Ligand)
Active human TGR5 complex with a synthetic agonist 23H
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7bw0
Q-score: 0.382
Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R
Signal Transduct Target Ther (2020) 5 pp. 142-142 [ Pubmed: 32747649 DOI: doi:10.1038/s41392-020-00262-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Rattus norvegicus)
- Nanobody nb35 (17 kDa, Protein from Vicugna pacos)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Tgr5+gs (Complex)
- 4 (Cellular component from Bos taurus)
- 3 (Cellular component from Rattus norvegicus)
- 2 (Cellular component from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- 5 (Cellular component from Vicugna pacos)
- Soluble cytochrome b562,g-protein coupled bile acid receptor 1 (46 kDa, Protein from Homo sapiens)