cryo-EM structure of LST2 TOS peptide bound to human mTOR complex 1
Battaglioni S, Craigie LM, Filippini S, Maier T, Hall MN
PNAS (2024) 121 pp. e2405959121-e2405959121 [ Pubmed: 39141345 DOI: doi:10.1073/pnas.2405959121 ]
- Lateral signaling target protein 2 homolog (1 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Regulatory-associated protein of mtor (152 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Mtorc1 in complex with lst2 tos peptide (Complex from Homo sapiens)
K3DAK4 bimodule core of BGC11 from Brevibacillus brevis
Resolution: 6.8 Å
EM Method: Single-particle
Fitted PDBs: 7zsk
Q-score: 0.085
Tittes YU, Herbst DA, Martin SFX, Munoz-Hernandez H, Jakob RP, Maier T
Sci Adv (2022) 8 pp. eabo6918-eabo6918 [ DOI: doi:10.1126/sciadv.abo6918 Pubmed: 36129979 ]
Composite map of the occluded conformation of neurofibromin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7r03
Q-score: 0.257
Chaker-Margot M, Werten S, Dunzendorfer-Matt T, Lechner S, Ruepp A, Scheffzek K, Maier T
Mol Cell (2022) 82 pp. 1288- [ DOI: doi:10.1016/j.molcel.2022.03.011 Pubmed: 35353986 ]
- Neurofibromin (640 MDa, Complex from Homo sapiens)
- Isoform i of neurofibromin (317 kDa, Protein from Homo sapiens)
Composite map of the open conformation of neurofibromin
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7r04
Q-score: 0.279
Chaker-Margot M, Werten S, Dunzendorfer-Matt T, Lechner S, Ruepp A, Scheffzek K, Maier T
Mol Cell (2022) 82 pp. 1288- [ DOI: doi:10.1016/j.molcel.2022.03.011 Pubmed: 35353986 ]
- Homodimer of neurofibromin (640 MDa, Complex from Homo sapiens)
- 5'-guanosine-diphosphate-monothiophosphate (539 Da, Ligand)
- Isoform i of neurofibromin (317 kDa, Protein from Homo sapiens)
human LonP1, R-state, incubated in AMPPCP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7oxo
Q-score: 0.298
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ Pubmed: 35870450 DOI: doi:10.1016/j.str.2022.06.006 ]
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Human mitochondrial lon protease homolog (639 kDa, Complex from Homo sapiens)
- Lon protease homolog, mitochondrial (106 kDa, Protein from Homo sapiens)
cryo-EM structure of DEPTOR bound to human mTOR complex 2, focussed on one protomer
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7pe8
Q-score: 0.448
Walchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T
eLife (2021) 10 [ Pubmed: 34519268 DOI: doi:10.7554/eLife.70871 ]
- Mtorc2 in complex with its regulator deptor (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dep domain-containing mtor-interacting protein (46 kDa, Protein from Homo sapiens)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Acetyl group (44 Da, Ligand)
- Serine/threonine-protein kinase mtor (291 kDa, Protein from Homo sapiens)
cryo-EM structure of DEPTOR bound to human mTOR complex 2, DEPt-bound subset local refinement
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7pe9
Q-score: 0.372
Walchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T
eLife (2021) 10 [ Pubmed: 34519268 DOI: doi:10.7554/eLife.70871 ]
- Mtorc2 in complex with its regulator deptor (1 MDa, Complex from Homo sapiens)
- Rapamycin-insensitive companion of mtor (192 kDa, Protein from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Dep domain-containing mtor-interacting protein (46 kDa, Protein from Homo sapiens)
- Target of rapamycin complex 2 subunit mapkap1 (59 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Acetyl group (44 Da, Ligand)
- Serine/threonine-protein kinase mtor (291 kDa, Protein from Homo sapiens)
cryo-EM structure of DEPTOR bound to human mTOR complex 1, focussed on one protomer
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 7peb
Q-score: 0.292
Walchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T
eLife (2021) 10 [ Pubmed: 34519268 DOI: doi:10.7554/eLife.70871 ]
- Mtorc1 in complex with its regulator deptor (1 MDa, Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Dep domain-containing mtor-interacting protein (46 kDa, Protein from Homo sapiens)
- Regulatory-associated protein of mtor (155 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (287 kDa, Protein from Homo sapiens)
cryo-EM structure of DEPTOR bound to human mTOR complex 1, DEPt-bound subset local refinement
Resolution: 4.24 Å
EM Method: Single-particle
Fitted PDBs: 7pec
Q-score: 0.24
Walchli M, Berneiser K, Mangia F, Imseng S, Craigie LM, Stuttfeld E, Hall MN, Maier T
eLife (2021) 10 [ Pubmed: 34519268 DOI: doi:10.7554/eLife.70871 ]
- Mtorc1 in complex with its regulator deptor (1 MDa, Complex from Homo sapiens)
- Inositol hexakisphosphate (660 Da, Ligand)
- Dep domain-containing mtor-interacting protein (46 kDa, Protein from Homo sapiens)
- Regulatory-associated protein of mtor (155 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Serine/threonine-protein kinase mtor (287 kDa, Protein from Homo sapiens)
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7ngf
Q-score: 0.206
Mohammed I, Schmitz KA, Schenck N, Balasopoulos D, Topitsch A, Maier T, Abrahams JP
Structure (2022) 30 pp. 1254-1268.e7 [ Pubmed: 35870450 DOI: doi:10.1016/j.str.2022.06.006 ]
- Lon protease homolog, mitochondrial (93 kDa, Protein from Homo sapiens)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- P2c-state of lonp1 hexameric complex in presence of atp/adp and bound endogenous substrate protein (600 kDa, Complex from Homo sapiens)
- Substrate protein chain:g (4 kDa, Protein from Homo sapiens)