Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
bioRxiv (2022) [ DOI: doi:10.1101/2022.01.25.477784 Pubmed: 35118469 ]
Structure of SARS-CoV S protein in complex with Receptor Binding Domain antibody DH1047
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 7sg4
Q-score: 0.355
Martinez DR, Schafer A, Gobeil S, Li D, De la Cruz G, Parks R, Lu X, Barr M, Stalls V, Janowska K, Beaudoin E, Manne K, Mansouri K, Edwards RJ, Cronin K, Yount B, Anasti K, Montgomery SA, Tang J, Golding H, Shen S, Zhou T, Kwong PD, Graham BS, Mascola JR, Montefiori DC, Alam SM, Sempowski G, Sempowski GD, Khurana S, Wiehe K, Saunders KO, Acharya P, Haynes BF, Baric RS
Sci Transl Med (2022) 14 pp. eabj7125-eabj7125 [ DOI: doi:10.1126/scitranslmed.abj7125 Pubmed: 34726473 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov s protein in complex with receptor binding domain antibody dh1047 (Complex from Severe acute respiratory syndrome-related coronavirus)
- Dh1047 light chain (24 kDa, Protein from Homo sapiens)
- Dh1047 heavy chain (24 kDa, Protein from Homo sapiens)
- Spike glycoprotein (140 kDa, Protein from Severe acute respiratory syndrome coronavirus)
SARS-CoV-2 Spike Protein Trimer bound to DH1043 fab
Resolution: 3.66 Å
EM Method: Single-particle
Fitted PDBs: 7ljr
Q-score: 0.35
Li D, Edwards RJ, Manne K, Martinez DR, Schafer A, Alam SM, Wiehe K, Lu X, Parks R, Sutherland LL, Oguin TH, McDanal C, Perez LG, Mansouri K, Gobeil SMC, Janowska K, Stalls V, Kopp M, Cai F, Lee E, Foulger A, Hernandez GE, Sanzone A, Tilahun K, Jiang C, Tse LV, Bock KW, Minai M, Nagata BM, Cronin K, Gee-Lai V, Deyton M, Barr M, Von Holle T, Macintyre AN, Stover E, Feldman J, Hauser BM, Caradonna TM, Scobey TD, Moody MA, Cain DW, DeMarco CT, Denny TN, Woods CW, Petzold EW, Schmidt AG, Teng IT, Zhou T, Kwong PD, Mascola JR, Graham BS, Moore IN, Seder R, Andersen H, Lewis MG, Montefiori DC, Sempowski GD, Baric RS, Acharya P, Haynes BF, Saunders KO
bioRxiv (2021) [ Pubmed: 33442694 DOI: doi:10.1101/2020.12.31.424729 ]
- Fab dh1043 heavy chain (51 kDa, Protein from Homo sapiens)
- Spike protein trimer bound to the dh1043 antibody (Complex from Severe acute respiratory syndrome coronavirus 2)
- Fab dh1043 light chain (25 kDa, Protein from Homo sapiens)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 7lwi
Q-score: 0.454
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 7lwj
Q-score: 0.363
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Resolution: 2.92 Å
EM Method: Single-particle
Fitted PDBs: 7lwk
Q-score: 0.501
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Resolution: 2.84 Å
EM Method: Single-particle
Fitted PDBs: 7lwl
Q-score: 0.515
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Resolution: 2.83 Å
EM Method: Single-particle
Fitted PDBs: 7lwm
Q-score: 0.521
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Resolution: 2.94 Å
EM Method: Single-particle
Fitted PDBs: 7lwn
Q-score: 0.502
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]
Mink Cluster 5-associated SARS-CoV-2 spike protein (S-GSAS-D614G-delFV) in the 1-RBD up conformation
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7lwo
Q-score: 0.51
Gobeil SM, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders KO, Edwards RJ, Korber B, Haynes BF, Henderson R, Acharya P
Science (2021) 373 [ DOI: doi:10.1126/science.abi6226 Pubmed: 34168071 ]