BG505 SOSIP.v5.2 in complex with VRC40.01 and RM19R Fabs
Resolution: 3.28 Å
EM Method: Single-particle
Fitted PDBs: 7lg6
Q-score: 0.484
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD
Cell Rep (2021) 37 pp. 109922-109922 [ Pubmed: 34731616 DOI: doi:10.1016/j.celrep.2021.109922 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm19r fab heavy chain (23 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc40.01 fab kappa light chain (23 kDa, Protein from Homo sapiens)
- Bg505 sosip.v5.2 in complex with vrc40.01 and rm19r fabs (Complex)
- Rm19r fab kappa light chain (23 kDa, Protein from Macaca mulatta)
- Vrc40.01 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc40.01 fab (Complex from Homo sapiens)
- Rm19r fab (Complex from Macaca mulatta)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.v5.2 (Complex from Human immunodeficiency virus 1)
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7llk
Q-score: 0.236
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD
Cell Rep (2021) 37 pp. 109922-109922 [ Pubmed: 34731616 DOI: doi:10.1016/j.celrep.2021.109922 ]
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 179nc75 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 179nc75 fab light chain (23 kDa, Protein from Homo sapiens)
- Trimeric hiv-1 env in complex with vrc33.01 fab (Complex from Human immunodeficiency virus 1)
Cryo-EM map of DH851.3 bound to HIV-1 CH505 Env
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7lu9
Q-score: 0.22
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh851.3 bound to hiv-1 ch505 env (Complex from Human immunodeficiency virus 1)
- Dh851.3 heavy chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 light chain (21 kDa, Protein from Macaca mulatta)
- Dh851.3 light chain (22 kDa, Protein from Macaca mulatta)
- Dh851.3 heavy chain (24 kDa, Protein from Macaca mulatta)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7ll1
Q-score: 0.414
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD
Cell Rep (2021) 37 pp. 109922-109922 [ Pubmed: 34731616 DOI: doi:10.1016/j.celrep.2021.109922 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc40.01 fab light chain (23 kDa, Protein from Homo sapiens)
- Trimer hiv-1 env in complex with vrc40.01 fab (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Vrc40.01 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.73 Å
EM Method: Single-particle
Fitted PDBs: 7ll2
Q-score: 0.424
Cottrell CA, Manne K, Kong R, Wang S, Zhou T, Chuang GY, Edwards RJ, Henderson R, Janowska K, Kopp M, Lin BC, Louder MK, Olia AS, Rawi R, Shen CH, Taft JD, Torres JL, Wu NR, Zhang B, Doria-Rose NA, Cohen MS, Haynes BF, Shapiro L, Ward AB, Acharya P, Mascola JR, Kwong PD
Cell Rep (2021) 37 pp. 109922-109922 [ Pubmed: 34731616 DOI: doi:10.1016/j.celrep.2021.109922 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vrc33.01 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc33.01 fab light chain (23 kDa, Protein from Homo sapiens)
- Trimeric hiv-1 env in complex with vrc33.01 fab (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Manne K, Stalls V, Hsu AL, Borgnia MJ, Stewart-Jones G, Lee MS, Bronkema N, Perfect J, Moody MA, Wiehe K, Bradley T, Kepler TB, Alam SM, Foulger A, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelso G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
bioRxiv (2020) https://doi.org/10.1101/2020.06.30.178921 [ DOI: doi:10.1101/2020.06.30.178921 ]
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fab-dimer bound near the cd4 binding site of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
- Antibody dh898.1 fragment antigen binding (fab) light chain (Protein from Macaca mulatta)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (304 kDa, Complex)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) dimer (94 kDa, Complex from Macaca mulatta)
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (210 kDa, Complex from Human immunodeficiency virus 1)
Cryo-electron microcospy reconstruction of CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 HIV Env
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l6o
Q-score: 0.426
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp120 (Protein from Human immunodeficiency virus 1)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 unliganded trimer in the presence of but not bound to dh898.1 fab (209 kDa, Complex from Human immunodeficiency virus 1)
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp41 (Protein from Human immunodeficiency virus 1)