DH270.6 Fab bound to the HIV-1 CH848 DE3 SOSIP
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8vgv
Q-score: 0.453
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Ch848 de3 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Dh270.6 antibody fab heavy chain (14 kDa, Protein from Homo sapiens)
- Dh270.6 antibody fab light chain (11 kDa, Protein from Homo sapiens)
- Ch848 de3 sosip gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
VRC01 Fab bound to the HIV-1 CH848 DE3 SOSIP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vgw
Q-score: 0.426
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch848 de3 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Ch848 de3 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Vrc01 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Vrc01 fab light chain (11 kDa, Protein from Homo sapiens)
CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.08 Å
EM Method: Single-particle
Fitted PDBs: 8vh1
Q-score: 0.404
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Ch505.m5 sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch235.i60 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Ch505.m5 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.i60 fab light chain (23 kDa, Protein from Homo sapiens)
CH235.12 Fab bound to the HIV-1 CH505.M5 SOSIP
Resolution: 4.31 Å
EM Method: Single-particle
Fitted PDBs: 8vh2
Q-score: 0.32
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Antibody fab bound hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
- Ch505.m5.g458y sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
CH505.M5.G458Y CE2 Design SOSIP
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 8vh3
Q-score: 0.433
Henderson R, Anasti K, Manne K, Stalls V, Saunders C, Bililign Y, Williams A, Bubphamala P, Montani M, Kachhap S, Li J, Jaing C, Newman A, Cain DW, Lu X, Venkatayogi S, Berry M, Wagh K, Korber B, Saunders KO, Tian M, Alt F, Wiehe K, Acharya P, Alam SM, Haynes BF
Nat Commun (2024) 15 pp. 9503-9503 [ DOI: doi:10.1038/s41467-024-53120-9 Pubmed: 39489734 ]
- Ch505.ce2 sosip gp41 (16 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 ectodomain (Complex from Human immunodeficiency virus 1)
- Ch505.ce2 sosip gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7t9t
Q-score: 0.382
To Be Published
- Trimeric hiv-1 env in complex with ch235.12 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp160 (51 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7tcn
Q-score: 0.346
To Be Published
- Trimeric hiv-1 env in complex with ch235.12 (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (54 kDa, Protein from Human immunodeficiency virus 1)
- Glycoprotein 41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
Resolution: 4.19 Å
EM Method: Single-particle
Fitted PDBs: 7tco
Q-score: 0.334
To Be Published
- Trimeric hiv-1 env in complex with ch235.12 (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Ch235.12 fab heavy chain (24 kDa, Protein from Homo sapiens)
- Glycoprotein 41 (18 kDa, Protein from Human immunodeficiency virus 1)
- Ch235.12 fab light chain (23 kDa, Protein from Homo sapiens)
Resolution: 3.84 Å
EM Method: Single-particle
Fitted PDBs: 8csa
Q-score: 0.33
Gobeil SM-C, Janowska K, McDowell S, Mansouri K, Parks R, Stalls V, Kopp MF, Manne K, Li D, Wiehe K, Saunders K, Edwards RJ, Korber B, Haynes BF, Henderson RC, Acharya P
Science (2021) [ DOI: doi:10.1126/science.abi6226 ]
Resolution: 3.68 Å
EM Method: Single-particle
Fitted PDBs: 7tge
Q-score: 0.342
Gobeil SM, Henderson R, Stalls V, Janowska K, Huang X, May A, Speakman M, Beaudoin E, Manne K, Li D, Parks R, Barr M, Deyton M, Martin M, Mansouri K, Edwards RJ, Eaton A, Montefiori DC, Sempowski GD, Saunders KO, Wiehe K, Williams W, Korber B, Haynes BF, Acharya P
Mol Cell (2022) 82 pp. 2050-2068.e6 [ Pubmed: 35447081 DOI: doi:10.1016/j.molcel.2022.03.028 ]