RMC-5552 in complex with mTORC1 and FKBP12
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8era
Q-score: 0.42
Burnett GL, Yang YC, Aggen JB, Pitzen J, Gliedt MK, Semko CM, Marquez A, Evans JW, Wang G, Won WS, Tomlinson ACA, Kiss G, Tzitzilonis C, Thottumkara AP, Cregg J, Mellem KT, Choi JS, Lee JC, Zhao Y, Lee BJ, Meyerowitz JG, Knox JE, Jiang J, Wang Z, Wildes D, Wang Z, Singh M, Smith JAM, Gill AL
J Med Chem (2023) 66 pp. 149-169 [ DOI: doi:10.1021/acs.jmedchem.2c01658 Pubmed: 36533617 ]
- Regulatory-associated protein of mtor (149 kDa, Protein from Homo sapiens)
- (3s,5r,6r,7e,9r,10r,12r,14s,15e,17e,19e,21s,23s,26r,27r,30r,34as)-5,9,27-trihydroxy-3-{(2r)-1-[(1s,3r,4r)-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-5,6,9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-octadecahydro-3h-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,11,28,29(4h,31h)-tetrone (916 Da, Ligand)
- Peptidyl-prolyl cis-trans isomerase fkbp1a (11 kDa, Protein from Homo sapiens)
- 1-[6-{[(3m)-4-amino-3-(2-amino-1,3-benzoxazol-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-1-yl]methyl}-3,4-dihydroisoquinolin-2(1h)-yl]-3-hydroxypropan-1-one (484 Da, Ligand)
- Serine/threonine-protein kinase mtor (289 kDa, Protein from Homo sapiens)
- Target of rapamycin complex subunit lst8 (35 kDa, Protein from Homo sapiens)
- Rmc-5552-mtorc1-fkbp12 (Complex from Homo sapiens)
CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7ul2
Q-score: 0.645
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Nanobody 6 (14 kDa, Protein from Lama glama)
- Nb6 (Complex from Lama glama)
- Water (18 Da, Ligand)
- 2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic acid (587 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Ntsr1 (Complex from Homo sapiens)
- Complex of ntsr1 and nb6 (Complex from Homo sapiens)
- Neurotensin receptor 1 (47 kDa, Protein from Homo sapiens)
CryoEM Structure of Inactive H2R Bound to Famotidine, Nb6M, and NabFab
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ul3
Q-score: 0.36
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Nb6m (Complex from Lama glama)
- Nabfab (Complex from synthetic construct)
- H2r (Complex from Homo sapiens)
- Histamine h2 receptor (44 kDa, Protein from Homo sapiens)
- Nabfab lc (23 kDa, Protein from synthetic construct)
- Nanobody 6m (14 kDa, Protein from synthetic construct)
- Nabfab hc (25 kDa, Protein from synthetic construct)
- Complex of h2r, nb6m, and nabfab (Complex from Homo sapiens)
- Famotidine (339 Da, Ligand)
CryoEM Structure of Inactive MOR Bound to Alvimopan and Mb6
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ul4
Q-score: 0.563
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Mb6 (Complex from Lama glama)
- Water (18 Da, Ligand)
- Complex of mor and nb6 (Complex from Mus musculus)
- Mor (Complex from Mus musculus)
- N-[(2s)-2-{[(3r,4r)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]methyl}-3-phenylpropanoyl]glycine (424 Da, Ligand)
- Mu-type opioid receptor (47 kDa, Protein from Mus musculus)
- Megabody 6 (55 kDa, Protein from synthetic construct)
CryoEM Structure of Inactive SSTR2 bound to Nb6
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ul5
Q-score: 0.562
Robertson MJ, Papasergi-Scott MM, He F, Seven AB, Meyerowitz JG, Panova O, Peroto MC, Che T, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 1188-1195 [ DOI: doi:10.1038/s41594-022-00859-8 Pubmed: 36396979 ]
- Nanobody 6 (14 kDa, Protein from Lama glama)
- Nb6 (Complex from Lama glama)
- Complex of sstr2 and nb6 (Complex from Homo sapiens)
- Somatostatin receptor type 2 (46 kDa, Protein from Homo sapiens)
- Sstr2 (Complex from Homo sapiens)
LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7sf7
Q-score: 0.479
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ Pubmed: 35418682 DOI: doi:10.1038/s41586-022-04575-7 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Latrophilin 3 (adgrl3) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
- Isoform 1 of adhesion g protein-coupled receptor l3 (34 kDa, Protein from Homo sapiens)
GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7sf8
Q-score: 0.544
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ Pubmed: 35418682 DOI: doi:10.1038/s41586-022-04575-7 ]
- Isoform 2 of adhesion g-protein coupled receptor g1 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)
- Gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7ryc
Q-score: 0.551
Meyerowitz JG, Robertson MJ, Barros-Alvarez X, Panova O, Nwokonko RM, Gao Y, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 274-281 [ Pubmed: 35241813 DOI: doi:10.1038/s41594-022-00728-4 ]
- Magnesium ion (24 Da, Ligand)
- Oxytocin receptor (Complex from Homo sapiens)
- Oxytocin receptor signaling complex with oxytocin and minigq and an scfv (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2, guanine nucleotide-binding protein g(i) subunit alpha-2,guanine nucleotide-binding protein g(s) subunit alpha isoforms short (36 kDa, Protein from Homo sapiens)
- Oxytocin (Complex from Homo sapiens)
- Scfv16 (Complex from Mus musculus)
- Minigq (Complex from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Oxytocin receptor (49 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Oxytocin (1 kDa, Protein from Homo sapiens)
CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3.
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 7t10
Q-score: 0.615
Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 210-217 [ DOI: doi:10.1038/s41594-022-00727-5 Pubmed: 35210615 ]
- Somatostatin receptor 2 in complex with somatostatin-14 and gi3. (Complex)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Somatostatin-14 (1 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2,kappa-type opioid receptor (45 kDa, Protein from Homo sapiens)
CryoEM structure of somatostatin receptor 2 in complex with Octreotide and Gi3.
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7t11
Q-score: 0.53
Robertson MJ, Meyerowitz JG, Panova O, Borrelli K, Skiniotis G
Nat Struct Mol Biol (2022) 29 pp. 210-217 [ DOI: doi:10.1038/s41594-022-00727-5 Pubmed: 35210615 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (27 kDa, Protein from Mus musculus)
- Octreotide (1 kDa, Protein from synthetic construct)
- Somatostatin receptor 2 in complex with octreotide and gi3. (Complex)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Somatostatin receptor type 2,kappa-type opioid receptor (45 kDa, Protein from Homo sapiens)