Structure of dengue virus (DENV2) in complex with prM12, an anti-PrM monoclonal antibody
Resolution: 10.2 Å
EM Method: Single-particle
Fitted PDBs: 8fe3
Q-score: 0.059
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Prm12 fab heavy chain (24 kDa, Protein from Mus musculus)
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
- Prm12 fab light chain (23 kDa, Protein from Mus musculus)
Structure of dengue virus (DENV2) in complex with prM13, an anti-PrM monoclonal antibody
Resolution: 9.8 Å
EM Method: Single-particle
Fitted PDBs: 8fe4
Q-score: 0.062
A Dowd K, Sirohi D, D Speer S, VanBlargan LA, Chen RE, Mukherjee S, Whitener BM, Govero J, Aleshnick M, Larman B, Sukupolvi-Petty S, Sevvana M, Miller AS, Klose T, Zheng A, Koenig S, Kielian M, Kuhn RJ, Diamond MS, Pierson TC
PNAS (2023) 120 pp. e2218899120-e2218899120 [ Pubmed: 36638211 DOI: doi:10.1073/pnas.2218899120 ]
- Prm13 fab light chain (23 kDa, Protein from Mus musculus)
- Envelope protein e (43 kDa, Protein from Dengue virus type 2)
- Dengue virus 2 (Virus from Dengue virus 2)
- Prm13 fab heavy chain (23 kDa, Protein from Mus musculus)
- Prm protein (9 kDa, Protein from Dengue virus type 2)
Zika Virus particle bound with IgM antibody DH1017 Fab fragment
Resolution: 5.26 Å
EM Method: Single-particle
Fitted PDBs: 7t17
Q-score: 0.264
Singh T, Hwang KK, Miller AS, Jones RL, Lopez CA, Dulson SJ, Giuberti C, Gladden MA, Miller I, Webster HS, Eudailey JA, Luo K, Von Holle T, Edwards RJ, Valencia S, Burgomaster KE, Zhang S, Mangold JF, Tu JJ, Dennis M, Alam SM, Premkumar L, Dietze R, Pierson TC, Ooi EE, Lazear HM, Kuhn RJ, Permar SR, Bonsignori M
Cell (2022) 185 pp. 4826-4840.e17 [ DOI: doi:10.1016/j.cell.2022.10.023 Pubmed: 36402135 ]
- Core protein (42 kDa, Protein from Zika virus)
- Zika virus (Virus from Zika virus)
- Dh1017.igm fabc constant domain (10 kDa, Protein from Homo sapiens)
- Dh1017.igm igl (11 kDa, Protein from Homo sapiens)
- Dh1017.igm igh (13 kDa, Protein from Homo sapiens)
- Dh1017.igm lambdac constant domain (11 kDa, Protein from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 7kcr
Q-score: 0.436
Sevvana M, Rogers TF, Miller AS, Long F, Klose T, Beutler N, Lai YC, Parren M, Walker LM, Buda G, Burton DR, Rossmann MG, Kuhn RJ
Viruses (2020) 12 [ Pubmed: 33255202 DOI: doi:10.3390/v12121346 ]
- Zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013 (Virus from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Zika virus in complex with monoclonal antibody adi30056 (15 MDa, Complex)
- Adi30056 fab light chain variable region (11 kDa, Protein from Homo sapiens)
- Adi30056 fab heavy chain variable region (13 kDa, Protein from Homo sapiens)
- Envelope protein e (54 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Membrane protein m (8 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- Monoclonal antibody adi30056 (Complex from Homo sapiens)
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 6mid
Q-score: 0.451
Long F, Doyle M, Fernandez E, Miller AS, Klose T, Sevvana M, Bryan A, Davidson E, Doranz BJ, Kuhn RJ, Diamond MS, Crowe Jr JE, Rossmann MG
PNAS (2019) 116 pp. 1591-1596 [ Pubmed: 30642974 DOI: doi:10.1073/pnas.1815432116 ]
- Monoclonal antibody zikv-195 heavy chain (14 kDa, Protein from Homo sapiens)
- Zikv virion in complex with fab fragments of the potently neutralizing human monoclonal antibody zikv-195 (Complex)
- Monoclonal antibody zikv-195 (Complex from Homo sapiens)
- E protein (54 kDa, Protein from Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013))
- Monoclonal antibody zikv-195 light chain (11 kDa, Protein from Homo sapiens)
- Zika virus (isolate zikv/human/french polynesia/10087pf/2013) (Virus from Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013))
- M protein (8 kDa, Protein from Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013))
Structure of Zika virus at a resolution of 3.1 Angstrom
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 6co8
Q-score: 0.507
Sevvana M, Long F, Miller AS, Klose T, Buda G, Sun L, Kuhn RJ, Rossmann MG
Structure (2018) 26 pp. 1169- [ DOI: doi:10.1016/j.str.2018.05.006 Pubmed: 29958768 ]
- Zika virus zikv/h. sapiens/frenchpolynesia/10087pf/2013 (Virus from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- M protein (8 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
- E protein (54 kDa, Protein from Zika virus ZIKV/H. sapiens/FrenchPolynesia/10087PF/2013)
Cryo-EM Structure of Immature Zika Virus
Resolution: 9.1 Å
EM Method: Single-particle
Fitted PDBs: 5u4w
Q-score: 0.079
Prasad VM, Miller AS, Klose T, Sirohi D, Buda G, Jiang W, Kuhn RJ, Rossmann MG
Nat Struct Mol Biol (2017) 24 pp. 184-186 [ DOI: doi:10.1038/nsmb.3352 Pubmed: 28067914 ]
- E protein (44 kDa, Protein from Zika virus)
- M protein (5 kDa, Protein from Zika virus)
- Transmembrane domains (Complex from Zika virus)
- Zika virus (Virus from Zika virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pr domain (9 kDa, Protein from Zika virus)
- Protein e (6 kDa, Protein from Zika virus)
- Beta-d-mannopyranose (180 Da, Ligand)