KDM2A-nucleosome structure stabilized by H3K36C-UNC8015 covalent conjugate
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7uv9
Q-score: 0.42
Spangler CJ, Skrajna A, Foley CA, Nguyen A, Budziszewski GR, Azzam DN, Arteaga EC, Simmons HC, Smith CB, Wesley NA, Wilkerson EM, McPherson JE, Kireev D, James LI, Frye SV, Goldfarb D, McGinty RK
Nat Chem Biol (2023) 19 pp. 624-632 [ Pubmed: 36797403 DOI: doi:10.1038/s41589-023-01256-y ]
- Histone h3.2 (15 kDa, Protein from Homo sapiens)
- Lysine-specific demethylase 2a (79 kDa, Protein from Homo sapiens)
- Dna (185-mer) (56 kDa, DNA from synthetic construct)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h4 (11 kDa, Protein from Homo sapiens)
- Dna (185-mer) (57 kDa, DNA from synthetic construct)
- Kdm2a-nucleosome complex stabilized by h3k36c-unc8015 covalent conjugate (310 kDa, Complex from Homo sapiens)
- Histone h2a type 1 (13 kDa, Protein from Homo sapiens)
- Fe (iii) ion (55 Da, Ligand)
- N-heptanoyl-n-hydroxy-beta-alanine (217 Da, Ligand)
KDM2B-nucleosome complex stabilized by H3K36C-UNC8015 covalent conjugate
Spangler CJ, Skrajna A, Foley CA, Nguyen A, Budziszewski GR, Azzam DN, Arteaga EC, Simmons HC, Smith CB, Wesley NA, Wilkerson EM, McPherson JE, Kireev D, James LI, Frye SV, Goldfarb D, McGinty RK
Nat Chem Biol (2023) 19 pp. 624-632 [ Pubmed: 36797403 DOI: doi:10.1038/s41589-023-01256-y ]
- Human histone h3 (Protein from Homo sapiens)
- Human histone h4 (Protein from Homo sapiens)
- Kdm2b-nucleosome complex stabilized by h3k36c-unc8015 covalent conjugate (320 kDa, Complex from Homo sapiens)
- Dna 185-mer (DNA from synthetic construct)
- Human histone h2b (Protein from Homo sapiens)
- Lysine-specific demethylase 2b (kdm2b) (Protein from Homo sapiens)
- Human histone h2a (Protein from Homo sapiens)
Structure of Complement C5 in Complex with small molecule inhibitor and CVF
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 8ayh
Q-score: 0.516
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, McLaughlin D, Be C, Wiesmann C, Murphy J, Bolduc P, Mogi M, Duca J, Namil A, Capparelli M, Darsigny V, Meredith E, Tichkule R, Ferrara L, Heyder J, Liu F, Horton PA, Romanowski MJ, Schirle M, Mainolfi N, Anderson K, Michaud GA
Nat Chem Biol (2019) 15 pp. 666-668 [ Pubmed: 31209353 DOI: doi:10.1038/s41589-019-0303-9 ]
- Magnesium ion (24 Da, Ligand)
- Cobra venom factor (184 kDa, Protein from Naja kaouthia)
- Complement c5 alpha chain (112 kDa, Protein from Homo sapiens)
- Complement c5-inhibitor-cvf complex (320 kDa, Complex from Homo sapiens)
- Complement c5 beta chain (73 kDa, Protein from Homo sapiens)
- 5-methoxy-2-[[(1~{s})-1-(2-methoxyphenyl)ethyl]carbamoylamino]-4-(4-methylpentoxy)benzoic acid (444 Da, Ligand)