Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with nevirapine
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 7z24
Q-score: 0.494
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with nevirapine (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 7z29
Q-score: 0.463
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with nevirapine (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- 11-cyclopropyl-5,11-dihydro-4-methyl-6h-dipyrido[3,2-b:2',3'-e][1,4]diazepin-6-one (266 Da, Ligand)
Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with rilpivirine
Resolution: 3.38 Å
EM Method: Single-particle
Fitted PDBs: 7z2d
Q-score: 0.452
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- 4-{[4-({4-[(e)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile (366 Da, Ligand)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with rilpivirine (Complex from Human immunodeficiency virus type 1 BH10)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7z2e
Q-score: 0.448
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with rilpivirine (Complex from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- 4-{[4-({4-[(e)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile (366 Da, Ligand)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
Cryo-EM structure of HIV-1 reverse transcriptase with a DNA aptamer in complex with doravirine
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7z2g
Q-score: 0.466
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Hiv-1 reverse transcriptase p51 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile (425 Da, Ligand)
- Hiv-1 reverse transcriptase p66 subunit (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase with a dna aptamer in complex with doravirine (Complex from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Reverse transcriptase/ribonuclease h (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
Resolution: 3.58 Å
EM Method: Single-particle
Fitted PDBs: 7z2h
Q-score: 0.384
Singh AK, De Wijngaert B, Bijnens M, Uyttersprot K, Nguyen H, Martinez SE, Schols D, Herdewijn P, Pannecouque C, Arnold E, Das K
PNAS (2022) 119 pp. e2203660119-e2203660119 [ Pubmed: 35858448 DOI: doi:10.1073/pnas.2203660119 ]
- Dna (38-mer) (11 kDa, DNA from synthetic construct)
- Hiv-1 reverse transcriptase p51 subunit with e138k mutation (Complex from Human immunodeficiency virus type 1 BH10)
- Hiv-1 reverse transcriptase p66 subunit with m184i mutation (Complex from Human immunodeficiency virus type 1 BH10)
- P51 rt (50 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- 3-chloro-5-({1-[(4-methyl-5-oxo-4,5-dihydro-1h-1,2,4-triazol-3-yl)methyl]-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridin-3-yl}oxy)benzonitrile (425 Da, Ligand)
- Reverse transcriptase/ribonuclease h (64 kDa, Protein from Human immunodeficiency virus type 1 BH10)
- Nnrti resistant m184i/e138k mutant hiv-1 reverse transcriptase with a dna aptamer in complex with doravirine (Complex from Human immunodeficiency virus type 1 BH10)