Cryo-EM structure of the full-length human P2X4 receptor in the apo closed state
Shi H, Ditter IA, Oken AC, Mansoor SE
Sci Adv (2025) 11 pp. eadr3315-eadr3315 [ Pubmed: 39823330 DOI: doi:10.1126/sciadv.adr3315 ]
- Water (18 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- P2x purinoceptor 4 (43 kDa, Protein from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of BAY-1797 bound to the full-length human P2X4 receptor in the closed state
Shi H, Ditter IA, Oken AC, Mansoor SE
Sci Adv (2025) 11 pp. eadr3315-eadr3315 [ Pubmed: 39823330 DOI: doi:10.1126/sciadv.adr3315 ]
- Water (18 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- N-[4-(3-chloranylphenoxy)-3-sulfamoyl-phenyl]-2-phenyl-ethanamide (416 Da, Ligand)
- P2x purinoceptor 4 (43 kDa, Protein from Homo sapiens)
- Dodecyl-beta-d-maltoside (510 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the full-length human P2X4 receptor in the ATP-bound desensitized state
Shi H, Ditter IA, Oken AC, Mansoor SE
Sci Adv (2025) 11 pp. eadr3315-eadr3315 [ Pubmed: 39823330 DOI: doi:10.1126/sciadv.adr3315 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- P2x purinoceptor 4 (43 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the human P2X1 receptor in the apo closed state
Resolution: 2.74 Å
EM Method: Single-particle
Fitted PDBs: 9c2a
Q-score: 0.536
Oken AC, Lisi NE, Ditter IA, Shi H, Nechiporuk NA, Mansoor SE
Nat Commun (2024) 15 pp. 8490-8490 [ DOI: doi:10.1038/s41467-024-52636-4 Pubmed: 39353889 ]
- Water (18 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- P2x purinoceptor 1 (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the human P2X1 receptor in the ATP-bound desensitized state
Resolution: 2.42 Å
EM Method: Single-particle
Fitted PDBs: 9c2b
Q-score: 0.637
Oken AC, Lisi NE, Ditter IA, Shi H, Nechiporuk NA, Mansoor SE
Nat Commun (2024) 15 pp. 8490-8490 [ DOI: doi:10.1038/s41467-024-52636-4 Pubmed: 39353889 ]
- Magnesium ion (24 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Water (18 Da, Ligand)
- Membrane protein (Complex from Homo sapiens)
- P2x purinoceptor 1 (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the human P2X1 receptor in the NF449-bound inhibited state
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 9c2c
Q-score: 0.491
Oken AC, Lisi NE, Ditter IA, Shi H, Nechiporuk NA, Mansoor SE
Nat Commun (2024) 15 pp. 8490-8490 [ DOI: doi:10.1038/s41467-024-52636-4 Pubmed: 39353889 ]
- Membrane protein (Complex from Homo sapiens)
- P2x purinoceptor 1 (45 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 4,4',4'',4'''-{carbonylbis[azanediylbenzene-5,1,3-triylbis(carbonylazanediyl)]}tetra(benzene-1,3-disulfonic acid) (1 kDa, Ligand)