Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A438079
Resolution: 2.18 Å
EM Method: Single-particle
Fitted PDBs: 8tr6
Q-score: 0.669
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- 3-{[(5r)-5-(2,3-dichlorophenyl)tetrazolidin-1-yl]methyl}pyridine (310 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist A839977
Resolution: 2.53 Å
EM Method: Single-particle
Fitted PDBs: 8tr7
Q-score: 0.619
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand from Rattus)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- (1p)-1-(2,3-dichlorophenyl)-n-({2-[(pyridin-2-yl)oxy]phenyl}methyl)-1h-tetrazol-5-amine (413 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist AZD9056
Resolution: 2.21 Å
EM Method: Single-particle
Fitted PDBs: 8tr8
Q-score: 0.66
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- N-{[(3s,5s,7s)-adamantan-1-yl]methyl}-2-chloro-5-{3-[(3-hydroxypropyl)amino]propyl}benzamide (419 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist GSK1482160
Resolution: 2.41 Å
EM Method: Single-particle
Fitted PDBs: 8tra
Q-score: 0.632
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Palmitic acid (256 Da, Ligand from Rattus)
- N-{[2-chloro-3-(trifluoromethyl)phenyl]methyl}-1-methyl-5-oxo-l-prolinamide (334 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist JNJ47965567
Resolution: 2.36 Å
EM Method: Single-particle
Fitted PDBs: 8trb
Q-score: 0.641
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- N-{[4-(4-phenylpiperazin-1-yl)oxan-4-yl]methyl}-2-(phenylsulfanyl)pyridine-3-carboxamide (488 Da, Ligand)
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the allosteric antagonist methyl blue
Resolution: 2.69 Å
EM Method: Single-particle
Fitted PDBs: 8trk
Q-score: 0.573
Oken AC, Ditter IA, Lisi NE, Krishnamurthy I, Godsey MH, Mansoor SE
Sci Adv (2024) 10 pp. eado5084-eado5084 [ DOI: doi:10.1126/sciadv.ado5084 Pubmed: 39365862 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- 4,4',4''-[methanetriyltris(4,1-phenyleneazanediyl)]tri(benzene-1-sulfonic acid) (757 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in the apo closed state
Oken AC, Lisi NE, Krishnamurthy I, McCarthy AE, Godsey MH, Glasfeld A, Mansoor SE
Nat Commun (2024) 15 pp. 6662-6662 [ DOI: doi:10.1038/s41467-024-50771-6 Pubmed: 39107314 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Sodium ion (22 Da, Ligand)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in complex with the high-affinity agonist BzATP
Oken AC, Lisi NE, Krishnamurthy I, McCarthy AE, Godsey MH, Glasfeld A, Mansoor SE
Nat Commun (2024) 15 pp. 6662-6662 [ DOI: doi:10.1038/s41467-024-50771-6 Pubmed: 39107314 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Palmitic acid (256 Da, Ligand from Rattus)
- 3'-o-(4-benzoylbenzoyl)adenosine 5'-(tetrahydrogen triphosphate) (715 Da, Ligand)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the rat P2X7 receptor in the apo closed state purified in the absence of sodium
Oken AC, Lisi NE, Krishnamurthy I, McCarthy AE, Godsey MH, Glasfeld A, Mansoor SE
Nat Commun (2024) 15 pp. 6662-6662 [ DOI: doi:10.1038/s41467-024-50771-6 Pubmed: 39107314 ]
- Guanosine-5'-diphosphate (443 Da, Ligand)
- Water (18 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Membrane protein (Complex from Rattus)
- Palmitic acid (256 Da, Ligand from Rattus)
- P2x purinoceptor 7 (68 kDa, Protein from Rattus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)