Cryo-EM structure of PCSK9 mimic HIT01-K21Q-R218E with AMG145 Fab
Zhang B, Chuang GY, Biju A, Biner D, Cheng J, Wang Y, Bao S, Chao CW, Lei H, Liu T, Nazzari AF, Yang Y, Zhou T, Chen SJ, Chen X, Kong WP, Ou L, Parchment DK, Sarfo EK, SiMa H, Todd JP, Wang S, Woodward RA, Cheng C, Rawi R, Mascola JR, Kwong PD
Cell Rep (2024) 43 pp. 114285-114285 [ DOI: doi:10.1016/j.celrep.2024.114285 Pubmed: 38819987 ]
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 8f7t
Q-score: 0.351
Olia AS, Cheng C, Zhou T, Biju A, Harris DR, Changela A, Duan H, Ivleva VB, Kong WP, Ou L, Rawi R, Tsybovsky Y, Van Wazer DJ, Corrigan AR, Gonelli CA, Lee M, McKee K, Narpala S, O'Dell S, Parchment DK, Stancofski ED, Stephens T, Tan I, Teng IT, Wang S, Wei Q, Yang Y, Yang Z, Zhang B, Novak J, Renfrow MB, Doria-Rose NA, Koup RA, McDermott AB, Gall JG, Lei QP, Mascola JR, Kwong PD
iScience (2023) 26 pp. 107403-107403 [ Pubmed: 37554450 DOI: doi:10.1016/j.isci.2023.107403 ]
- Hiv-1 env gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hiv-1 consensus c env trimer with glycan covered base (Complex from Human immunodeficiency virus 1)
- Hiv-1 env gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Vaccine-elicited human antibody 2C06 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.95 Å
EM Method: Single-particle
Fitted PDBs: 8g4m
Q-score: 0.564
Wang S, Matassoli F, Zhang B, Liu T, Shen CH, Bylund T, Johnston T, Henry AR, Teng IT, Tripathi P, Becker JE, Changela A, Chaudhary R, Cheng C, Gaudinski M, Gorman J, Harris DR, Lee M, Morano NC, Novik L, O'Dell S, Olia AS, Parchment DK, Rawi R, Roberts-Torres J, Stephens T, Tsybovsky Y, Wang D, Van Wazer DJ, Zhou T, Doria-Rose NA, Koup RA, Shapiro L, Douek DC, McDermott AB, Kwong PD
Cell Rep (2023) 42 pp. 112755-112755 [ DOI: doi:10.1016/j.celrep.2023.112755 Pubmed: 37436899 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Antibody light chain (23 kDa, Protein from Homo sapiens)
- Antibody heavy chain (25 kDa, Protein from Homo sapiens)
- Hiv envelope trimer in complex with three copies of antibody fab (Complex)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
Vaccine-elicited human antibody 2C09 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.81 Å
EM Method: Single-particle
Fitted PDBs: 8g4t
Q-score: 0.56
Wang S, Matassoli F, Zhang B, Liu T, Shen CH, Bylund T, Johnston T, Henry AR, Teng IT, Tripathi P, Becker JE, Changela A, Chaudhary R, Cheng C, Gaudinski M, Gorman J, Harris DR, Lee M, Morano NC, Novik L, O'Dell S, Olia AS, Parchment DK, Rawi R, Roberts-Torres J, Stephens T, Tsybovsky Y, Wang D, Van Wazer DJ, Zhou T, Doria-Rose NA, Koup RA, Shapiro L, Douek DC, McDermott AB, Kwong PD
Cell Rep (2023) 42 pp. 112755-112755 [ DOI: doi:10.1016/j.celrep.2023.112755 Pubmed: 37436899 ]
- Fab 2c09 light chain (23 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Fab 2c09 heavy chain (24 kDa, Protein from Homo sapiens)
- Hiv envelope trimer in complex with three copies of antibody fab (Complex)
- Envelope glycoprotein bg505 ds-sosip gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein bg505 ds-sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8fr6
Q-score: 0.528
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- Antibody fab (Complex from Mus musculus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Complex of antibody fab vfp53.02 with hiv-1 env trimer bg505 ds-sosip (Complex)
- Vfp53.02 fab heavy chain (24 kDa, Protein from Mus musculus)
- Hiv-1 env trimer bg505 ds-sosip (Complex from Human immunodeficiency virus 1)
- Vfp53.02 fab light chain (24 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
vFP52.02 Fab in complex with BG505 DS-SOSIP Env trimer
Resolution: 3.99 Å
EM Method: Single-particle
Fitted PDBs: 8g85
Q-score: 0.323
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp52.02 heavy (13 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp52.02 light (11 kDa, Protein from Mus musculus)
- Vfp52.02 fab in complex with bg505 ds-sosip env trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 1)
Resolution: 4.66 Å
EM Method: Single-particle
Fitted PDBs: 8g9w
Q-score: 0.237
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2)
Resolution: 4.46 Å
EM Method: Single-particle
Fitted PDBs: 8g9x
Q-score: 0.253
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 3)
Resolution: 4.28 Å
EM Method: Single-particle
Fitted PDBs: 8g9y
Q-score: 0.291
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp49.02 light chain (23 kDa, Protein from Mus musculus)
- Vfp49.02 fab in complex with bg505 ds-sosip.664 (Complex from Human immunodeficiency virus 1)
- Vfp49.02 heavy chain (25 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)
vFP48.02 Fab in complex with BG505 DS-SOSIP Env trimer
Resolution: 4.04 Å
EM Method: Single-particle
Fitted PDBs: 8gas
Q-score: 0.347
Sastry M, Changela A, Gorman J, Xu K, Chuang GY, Shen CH, Cheng C, Geng H, O'Dell S, Ou L, Rawi R, Reveiz M, Stewart-Jones GBE, Wang S, Zhang B, Zhou T, Biju A, Chambers M, Chen X, Corrigan AR, Lin BC, Louder MK, McKee K, Nazzari AF, Olia AS, Parchment DK, Sarfo EK, Stephens T, Stuckey J, Tsybovsky Y, Verardi R, Wang Y, Zheng CY, Chen Y, Doria-Rose NA, McDermott AB, Mascola JR, Kwong PD
J Virol (2023) 97 pp. e0160422-e0160422 [ Pubmed: 37098956 DOI: doi:10.1128/jvi.01604-22 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Vfp48.02 heavy chain (13 kDa, Protein from Mus musculus)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp48.02 light chain (12 kDa, Protein from Mus musculus)
- Vfp48.02 fab in complex with bg505 ds-sosip env trimer (Complex from Human immunodeficiency virus 1)
- Envelope glycoprotein gp120 (54 kDa, Protein from Human immunodeficiency virus 1)