BG505 GT1.1 SOSIP in complex with NHP Fabs 12C11 and RM20A3
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8sw3
Q-score: 0.564
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 12c11 heavy chain variable region (14 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 12c11 light chain variable region (11 kDa, Protein from Macaca)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip in complex with 12c11 fab and rm20a3 fab (720 kDa, Complex from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
BG505 GT1.1 SOSIP in complex with NHP Fabs 21N13, 21M20 and RM20A3
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8sw4
Q-score: 0.567
Caniels TG, Medina-Ramirez M, Zhang S, Kratochvil S, Xian Y, Koo JH, Derking R, Samsel J, van Schooten J, Pecetta S, Lamperti E, Yuan M, Carrasco MR, Del Moral Sanchez I, Allen JD, Bouhuijs JH, Yasmeen A, Ketas TJ, Snitselaar JL, Bijl TPL, Martin IC, Torres JL, Cupo A, Shirreff L, Rogers K, Mason RD, Roederer M, Greene KM, Gao H, Silva CM, Baken IJL, Tian M, Alt FW, Pulendran B, Seaman MS, Crispin M, van Gils MJ, Montefiori DC, McDermott AB, Villinger FJ, Koup RA, Moore JP, Klasse PJ, Ozorowski G, Batista FD, Wilson IA, Ward AB, Sanders RW
Sci Immunol (2024) 9 pp. eadk9550-eadk9550 [ Pubmed: 39213338 DOI: doi:10.1126/sciimmunol.adk9550 ]
- 21m20 heavy chain variable region (13 kDa, Protein from Macaca)
- Bg505 gt1.1 sosip gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 gt1.1 sosip in complex with 21n13 fab, 21m20 fab and rm20a3 fab (770 kDa, Complex from Macaca)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 21m20 light chain variable region (11 kDa, Protein from Macaca)
- 21n13 light chain variable region (11 kDa, Protein from Macaca)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rm20a3 heavy chain variable region (13 kDa, Protein from Macaca)
- 21n13 heavy chain variable region (14 kDa, Protein from Macaca)
- Rm20a3 light chain variable region (11 kDa, Protein from Macaca)
10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
ApexGT2 in complex with GT2-d42.16 and RM20A3 Fabs
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7t9a
Q-score: 0.456
Melzi E, Willis J, Ma K, Lin Y, Kratochvil S, Berndsen ZT, Nair U, Warner J, Steichen J, Pecetta S, Perez M, Kirsch K, Ward AB, Schief W, Batista FD
Immunity (2022) [ ]
- Gt2-d42.16 fab light chain (11 kDa, Protein from Mus musculus)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Hiv envelope apexgt2 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv envelope apexgt2 gp41 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Gt2-d42.16 fab heavy chain (15 kDa, Protein from Mus musculus)
- Hiv-1 envelope apexgt2 in complex with pct64_lmca.hl_gt2_d42.16 fab and rm20a3 fab (Complex from Human immunodeficiency virus 1)
ApexGT5 in complex with GT5-d42.16 and RM20A3 Fabs
Resolution: 3.72 Å
EM Method: Single-particle
Fitted PDBs: 7t9b
Q-score: 0.438
Melzi E, Willis J, Ma K, Lin Y, Kratochvil S, Berndsen ZT, Nair U, Warner J, Steichen J, Pecetta S, Perez M, Kirsch K, Ward AB, Schief W, Batista FD
Immunity (2022) [ ]
- Hiv-1 envelope apexgt5 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Gt5-d42.16 fab light chain (11 kDa, Protein from Mus musculus)
- Gt5-d42.16 fab heavy chain (15 kDa, Protein from Mus musculus)
- Hiv-1 envelope apexgt5 gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Hiv-1 envelope apexgt5 in complex with gt5-d42.16 and rm20a3 fabs (Complex from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6dfg
Q-score: 0.348
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Mature bg18 fragment antigen binding heavy chain (25 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 md39 sosip trimer in complex with mature bg18 fragment antigen binding (570 kDa, Complex)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Mature bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
- Bg18 fragment (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6dfh
Q-score: 0.392
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 md64 n332-gt2 sosip trimer in complex with germline-reverted bg18 fragment antigen binding (570 kDa, Complex)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg18 fragment antigen (Complex from Homo sapiens)
- Germline-reverted bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Hmp1 fragment antigen binding (Complex from Homo sapiens)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
- Bg18-like precursor hmp1 fragment antigen binding light chain (Protein from Homo sapiens)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp1 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Bg18-like precursor hmp1 fragment antigen binding heavy chain (Protein from Homo sapiens)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Hmp42 fragment antigen binding (Complex from Homo sapiens)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp42 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Bg505 md64 n332-gt5 sosip trimer (Complex from Human immunodeficiency virus 1)
- Bg18-like precursor hmp42 fragment antigen binding light chain (Protein from Homo sapiens)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Bg18-like precursor hmp42 fragment antigen binding heavy chain (Protein from Homo sapiens)