Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8x9s
Q-score: 0.506
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Complex of gpr133 with agonist and g protein trime (Complex from Bos taurus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 9iv1
Q-score: 0.478
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (41 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Adhesion g-protein coupled receptor d1 (34 kDa, Protein from Homo sapiens)
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 9iv2
Q-score: 0.503
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Gs protein alpha subunit (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in nanodisc
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgi
Q-score: 0.293
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Tmem16a in nanodsic (Cell from Mus musculus)
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the TMEM16A calcium-activated chloride channel in LMNG
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6bgj
Q-score: 0.296
Dang S, Feng S, Tien J, Peters CJ, Bulkley D, Lolicato M, Zhao J, Zuberbuhler K, Ye W, Qi L, Chen T, Craik CS, Nung Jan Y, Minor DL, Cheng Y, Yeh Jan L
Nature (2017) 552 pp. 426-429 [ Pubmed: 29236684 DOI: doi:10.1038/nature25024 ]
- Tmem16a calcium-activated chloride channel (Cell from Mus musculus)
- Anoctamin-1 (105 kDa, Protein from Mus musculus)
- Calcium ion (40 Da, Ligand)