Structure of AT118-H Nanobody Antagonist in Complex with the Angiotensin II Type I Receptor
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8th3
Q-score: 0.532
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- At118-h nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion, anti-bril fab, and anti-fab nanobody (Complex from Homo sapiens)
- At118-h nanobody, type-1 angiotensin ii receptor, soluble cytochrome b562 complex (65 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8th4
Q-score: 0.495
Skiba MA, Sterling SM, Rawson S, Zhang S, Xu H, Jiang H, Nemeth GR, Gilman MSA, Hurley JD, Shen P, Staus DP, Kim J, McMahon C, Lehtinen MK, Rockman HA, Barth P, Wingler LM, Kruse AC
Nat Chem Biol (2024) 20 pp. 1577-1585 [ Pubmed: 38744986 DOI: doi:10.1038/s41589-024-01620-6 ]
- Bag2 anti-bril fab heavy chain (24 kDa, Protein from synthetic construct)
- [2-butyl-5-chloranyl-3-[[4-[2-(2h-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol (422 Da, Ligand)
- At118-l nanobody antagonist in complex with the angiotensin ii type i receptor bril fusion protein, anti-bril fab, anti-fab nanobody, and losartan (Complex from Homo sapiens)
- At118-l nanobody (15 kDa, Protein from synthetic construct)
- Type-1 angiotensin ii receptor soluble cytochrome b562 complex (49 kDa, Protein from Homo sapiens)
- Bag2 anti-bril fab light chain (23 kDa, Protein from synthetic construct)
Preholo-Proteasome from Beta 3 D205 deletion
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8u6y
Q-score: 0.513
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) 31 pp. 1167-1175 [ Pubmed: 38600323 DOI: doi:10.1038/s41594-024-01262-1 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome assembly chaperone 2 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome maturation factor ump1 (16 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome chaperone 1 (30 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Preholo-proteasome from beta 3 d205 deletion mutant (750 kDa, Complex from Saccharomyces cerevisiae S288C)
Proteasome 20S Core Particle from Beta 3 D205 deletion
Resolution: 2.16 Å
EM Method: Single-particle
Fitted PDBs: 8u7u
Q-score: 0.688
Velez B, Walsh Jr RM, Rawson S, Razi A, Adams L, Perez EF, Jiao F, Blickling M, Rajakumar T, Fung D, Huang L, Hanna J
Nat Struct Mol Biol (2024) 31 pp. 1167-1175 [ Pubmed: 38600323 DOI: doi:10.1038/s41594-024-01262-1 ]
- Proteasome subunit alpha type-1 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-4 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-7 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-3 (22 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-5 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-1 (23 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-6 (25 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-2 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-4 (28 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-6 (26 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-7 (29 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit alpha type-2 (27 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome subunit beta type-5 (31 kDa, Protein from Saccharomyces cerevisiae S288C)
- Proteasome 20s core particle from beta 3 d205 deletion mutant (700 kDa, Complex from Saccharomyces cerevisiae S288C)
Human 20S proteasome assembly intermediate structure 5 beta7 tagged
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
Human 20S core particle beta7 tagged
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
Human 20S proteasome assembly structure 1
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8qyj
Q-score: 0.602
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 4 (13 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Human 20s proteasome assembly intermediate map 1 (Complex from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (34 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 3 (13 kDa, Protein from Homo sapiens)
Human 20S proteasome assembly intermediate structure 2
Resolution: 2.67 Å
EM Method: Single-particle
Fitted PDBs: 8qyl
Q-score: 0.601
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Human 20s proteasome assembly intermediate map 2 (Complex from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (35 kDa, Protein from Homo sapiens)
Human 20S proteasome assembly intermediate structure 3
Resolution: 2.73 Å
EM Method: Single-particle
Fitted PDBs: 8qym
Q-score: 0.595
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Human 20s proteasome assembly intermediate map 3 (Complex from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (35 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
Human 20S proteasome assembly intermediate structure 5
Resolution: 2.88 Å
EM Method: Single-particle
Fitted PDBs: 8qyn
Q-score: 0.571
Adolf F, Du J, Goodall EA, Walsh Jr RM, Rawson S, von Gronau S, Harper JW, Hanna J, Schulman BA
Nat Struct Mol Biol (2024) 31 pp. 1176-1188 [ DOI: doi:10.1038/s41594-024-01268-9 Pubmed: 38600324 ]
- Human 20s proteasome assembly intermediate map 5 (Complex from Homo sapiens)
- Proteasome subunit beta type-5 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-2 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-6 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-3 (28 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-5 (26 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 1 (32 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-1 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-1 (26 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-7 (27 kDa, Protein from Homo sapiens)
- Proteasome subunit alpha type-2 (25 kDa, Protein from Homo sapiens)
- Proteasome maturation protein (15 kDa, Protein from Homo sapiens)
- Proteasome assembly chaperone 2 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-4 (29 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-3 (22 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-7 (35 kDa, Protein from Homo sapiens)
- Proteasome subunit beta type-6 (25 kDa, Protein from Homo sapiens)