Structure of the SARS-CoV-2 spike glycoprotein S2 subunit
Resolution: 3.67 Å
EM Method: Single-particle
Fitted PDBs: 8dya
Q-score: 0.382
Bowen JE, Park YJ, Stewart C, Brown JT, Sharkey WK, Walls AC, Joshi A, Sprouse KR, McCallum M, Tortorici MA, Franko NM, Logue JK, Mazzitelli IG, Nguyen AW, Silva RP, Huang Y, Low JS, Jerak J, Tiles SW, Ahmed K, Shariq A, Dan JM, Zhang Z, Weiskopf D, Sette A, Snell G, Posavad CM, Iqbal NT, Geffner J, Bandera A, Gori A, Sallusto F, Maynard JA, Crotty S, Van Voorhis WC, Simmerling C, Grifantini R, Chu HY, Corti D, Veesler D
Sci Immunol (2022) 7 pp. eadf1421-eadf1421 [ DOI: doi:10.1126/sciimmunol.adf1421 Pubmed: 36356052 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike s2 subunit (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein s2 subunit (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (68 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike protein bound to the S2P6 and S2M11 Fab fragments
Pinto D, Sauer MM, Czudnochowski N, Low JS, Tortorici MA, Housley MP, Noack J, Walls AC, Bowen JE, Guarino B, Rosen LE, di Iulio J, Jerak J, Kaiser H, Islam S, Jaconi S, Sprugasci N, Culap K, Abdelnabi R, Foo C, Coelmont L, Bartha I, Bianchi S, Silacci-Fregni C, Bassi J, Marzi R, Vetti E, Cassotta A, Ceschi A, Ferrari P, Cippa PE, Giannini O, Ceruti S, Garzoni C, Riva A, Benigni F, Cameroni E, Piccoli L, Pizzuto MS, Smithey M, Hong D, Telenti A, Lempp FA, Neyts J, Havenar-Daughton C, Lanzavecchia A, Sallusto F, Snell G, Virgin HW, Beltramello M, Corti D, Veesler D
Science (2021) 373 pp. 1109-1116 [ Pubmed: 34344823 DOI: doi:10.1126/science.abj3321 ]
- S2m11 fab fragment (Complex from Homo sapiens)
- S2p6 and s2m11 fab fragments bound to the sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- S2p6 fab fragment (Complex from Homo sapiens)
Resolution: 3.54 Å
EM Method: Single-particle
Fitted PDBs: 7khf
Q-score: 0.496
Chen Y, Xu K, Piccoli L, Foglierini M, Tan J, Jin W, Gorman J, Tsybovsky Y, Zhang B, Traore B, Silacci-Fregni C, Daubenberger C, Crompton PD, Geiger R, Sallusto F, Kwong PD, Lanzavecchia A
Nature (2021) 592 pp. 639-643 [ DOI: doi:10.1038/s41586-021-03378-6 Pubmed: 33790470 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rifin (15 kDa, Protein from Plasmodium falciparum (isolate 3D7))
- Mdb1 fab in complex with rifin (Complex from Homo sapiens)
- Mdb1 fab heavy chain (46 kDa, Protein from Homo sapiens)
- Mdb1 fab light chain (22 kDa, Protein from Homo sapiens)
- Mdb1 fab (Complex from Homo sapiens)
Perotti M, Marcandalli J, Demurtas D, Sallusto F, Perez L
PLoS Pathog (2020) 16 pp. e1009169-e1009169 [ Pubmed: 33370407 DOI: doi:10.1371/journal.ppat.1009169 ]
Perotti M, Marcandalli J, Demurtas D, Sallusto F, Perez L
PLoS Pathog (2020) 16 pp. e1009169-e1009169 [ Pubmed: 33370407 DOI: doi:10.1371/journal.ppat.1009169 ]
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7jv2
Q-score: 0.445
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ Pubmed: 32991844 DOI: doi:10.1016/j.cell.2020.09.037 ]
- S2h13 neutralizing antibody fab fragment (Complex from Homo sapiens)
- Sars-cov-2 spike in complex with the s2h13 neutralizing antibody fab fragment (Complex)
- S2h13 fab light chain (11 kDa, Protein from Homo sapiens)
- S2h13 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (one RBD open)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7jv4
Q-score: 0.397
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ Pubmed: 32991844 DOI: doi:10.1016/j.cell.2020.09.037 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2h13 neutralizing antibody fab fragment (Complex from Homo sapiens)
- Sars-cov-2 spike in complex with the s2h13 neutralizing antibody fab fragment (Complex)
- S2h13 fab light chain (11 kDa, Protein from Homo sapiens)
- S2h13 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with the S2H13 neutralizing antibody (closed conformation)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7jv6
Q-score: 0.433
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ Pubmed: 32991844 DOI: doi:10.1016/j.cell.2020.09.037 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- S2h13 neutralizing antibody fab fragment (Complex from Homo sapiens)
- Sars-cov-2 spike in complex with the s2h13 neutralizing antibody fab fragment (Complex)
- S2h13 fab light chain (11 kDa, Protein from Homo sapiens)
- S2h13 fab heavy chain (13 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7jva
Q-score: 0.452
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ Pubmed: 32991844 DOI: doi:10.1016/j.cell.2020.09.037 ]
- Sars-cov-2 spike in complex with the s2a4 neutralizing antibody fab fragment (Complex)
- S2a4 fab heavy chain (13 kDa, Protein from Homo sapiens)
- S2a4 fab light chain (11 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2a4 neutralizing antibody fab fragment (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with the S2A4 neutralizing antibody Fab fragment
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7jvc
Q-score: 0.391
Piccoli L, Park YJ, Tortorici MA, Czudnochowski N, Walls AC, Beltramello M, Silacci-Fregni C, Pinto D, Rosen LE, Bowen JE, Acton OJ, Jaconi S, Guarino B, Minola A, Zatta F, Sprugasci N, Bassi J, Peter A, De Marco A, Nix JC, Mele F, Jovic S, Rodriguez BF, Gupta SV, Jin F, Piumatti G, Lo Presti G, Pellanda AF, Biggiogero M, Tarkowski M, Pizzuto MS, Cameroni E, Havenar-Daughton C, Smithey M, Hong D, Lepori V, Albanese E, Ceschi A, Bernasconi E, Elzi L, Ferrari P, Garzoni C, Riva A, Snell G, Sallusto F, Fink K, Virgin HW, Lanzavecchia A, Corti D, Veesler D
Cell (2020) 183 pp. 1024-1042.e21 [ Pubmed: 32991844 DOI: doi:10.1016/j.cell.2020.09.037 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sars-cov-2 spike in complex with the s2a4 neutralizing antibody fab fragment (Complex)
- S2a4 fab heavy chain (24 kDa, Protein from Homo sapiens)
- S2a4 fab light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- S2a4 neutralizing antibody fab fragment (Complex from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)