Type I-F CRISPR-Csy complex with its inhibitor AcrF9
Resolution: 2.57 Å
EM Method: Single-particle
Fitted PDBs: 6vqv
Q-score: 0.495
Zhang K, Wang S, Li S, Zhu Y, Pintilie GD, Mou TC, Schmid MF, Huang Z, Chiu W
PNAS (2020) 117 pp. 7176-7182 [ DOI: doi:10.1073/pnas.1922638117 Pubmed: 32170016 ]
- Crrna (60-mer) (19 kDa, RNA from Pseudomonas aeruginosa)
- Crispr-associated protein csy1 (49 kDa, Protein from Pseudomonas aeruginosa)
- Crispr-associated protein csy2 (36 kDa, Protein from Pseudomonas aeruginosa)
- Crispr-associated protein csy3 (39 kDa, Protein from Pseudomonas aeruginosa)
- Type i-f crispr-csy complex with its inhibitor acrf9 (350 kDa, Complex from Pseudomonas aeruginosa)
- Crispr-associated endonuclease cas6/csy4 (21 kDa, Protein from Pseudomonas aeruginosa)
- Acrf9 (7 kDa, Protein from Pseudomonas aeruginosa)
Type I-F CRISPR-Csy complex with its inhibitor AcrF8
Resolution: 3.42 Å
EM Method: Single-particle
Fitted PDBs: 6vqw
Q-score: 0.462
Zhang K, Wang S, Li S, Zhu Y, Pintilie GD, Mou TC, Schmid MF, Huang Z, Chiu W
PNAS (2020) 117 pp. 7176-7182 [ DOI: doi:10.1073/pnas.1922638117 Pubmed: 32170016 ]
- Crispr-associated protein csy1 (49 kDa, Protein from Pseudomonas aeruginosa)
- Acrf8 (10 kDa, Protein from Pseudomonas aeruginosa)
- Type i-f crispr-csy complex with its inhibitor acrf8 (350 kDa, Complex from Pseudomonas aeruginosa)
- Type i-f crispr-associated protein csy2 (36 kDa, Protein from Pseudomonas aeruginosa)
- Crrna (40-mer) (19 kDa, RNA from Pseudomonas aeruginosa)
- Crispr-associated protein csy3 (39 kDa, Protein from Pseudomonas aeruginosa)
- Crispr-associated endonuclease cas6/csy4 (21 kDa, Protein from Pseudomonas aeruginosa)
Type I-F CRISPR-Csy complex with its inhibitor AcrF6
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 6vqx
Q-score: 0.433
Zhang K, Wang S, Li S, Zhu Y, Pintilie GD, Mou TC, Schmid MF, Huang Z, Chiu W
PNAS (2020) 117 pp. 7176-7182 [ DOI: doi:10.1073/pnas.1922638117 Pubmed: 32170016 ]
- Crrna (60-mer) (19 kDa, RNA from Pseudomonas aeruginosa)
- Crispr-associated protein csy1 (49 kDa, Protein from Pseudomonas aeruginosa)
- Type i-f crispr-associated protein csy2 (36 kDa, Protein from Pseudomonas aeruginosa)
- Acrf6 (10 kDa, Protein from Pseudomonas aeruginosa)
- Crispr-associated protein csy3 (39 kDa, Protein from Pseudomonas aeruginosa)
- Type i-f crispr-csy complex with its inhibitor acrf6 (350 kDa, Complex from Pseudomonas aeruginosa)
- Crispr-associated endonuclease cas6/csy4 (21 kDa, Protein from Pseudomonas aeruginosa)
Asymmetric structure of AcrAB-TolC tripartite multi drug efflux pump
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 5o66
Q-score: 0.24
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli (strain K12))
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli (strain K12))
- Acrabz-tolc (Complex from Escherichia coli K12)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli (strain K12))
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5ng5
Q-score: 0.326
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- Multidrug efflux pump accessory protein acrz (5 kDa, Protein from Escherichia coli)
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- 6-[2-(3,4-dimethoxyphenyl)ethylsulfanyl]-8-[4-(2-methoxyethyl)piperazin-1-yl]-3,3-dimethyl-1,4-dihydropyrano[3,4-c]pyridine-5-carbonitrile (526 Da, Ligand)
- Multidrug efflux pump subunit acra (39 kDa, Protein from Escherichia coli)
- Outer membrane protein tolc (53 kDa, Protein from Escherichia coli)
multi-drug efflux; membrane transport; RND superfamily; Drug resistance
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 5v5s
Q-score: 0.193
Wang Z, Fan G, Hryc CF, Blaza JN, Serysheva II, Schmid MF, Chiu W, Luisi BF, Du D
eLife (2017) 6 [ DOI: doi:10.7554/eLife.24905 Pubmed: 28355133 ]
- Multidrug efflux pump subunit acrb (113 kDa, Protein from Escherichia coli )
- Multidrug efflux pump subunit acra (42 kDa, Protein from Escherichia coli)
- Acrabtolc in apo state (Complex from Escherichia coli)
- Outer membrane protein tolc (48 kDa, Protein from Escherichia coli)
Bacteriophage P22 mature virion capsid protein
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 5uu5
Q-score: 0.548
Hryc CF, Chen DH, Afonine PV, Jakana J, Wang Z, Haase-Pettingell C, Jiang W, Adams PD, King JA, Schmid MF, Chiu W
PNAS (2017) 114 pp. 3103-3108 [ DOI: doi:10.1073/pnas.1621152114 Pubmed: 28270620 ]
- Major capsid protein (46 kDa, Protein from Salmonella phage P22)
- Enterobacteria phage p22 (327 MDa, Virus from Enterobacteria phage P22)
Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW
Mol Cell (2015) 57 pp. 1047-1058 [ Pubmed: 25728767 DOI: doi:10.1016/j.molcel.2015.01.025 ]
- P300 (300 kDa, Sample)
- Histone acetyltransferase p300 (300 kDa, Protein from Homo sapiens)
Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW
Mol Cell (2015) 57 pp. 1047-1058 [ Pubmed: 25728767 DOI: doi:10.1016/j.molcel.2015.01.025 ]
- P300 bound to antibody 1 (400 kDa, Sample)
- Antibody 1 (Protein from unidentified)
- Histone acetyltransferase p300 (300 kDa, Protein from Homo sapiens)
Yi P, Wang Z, Feng Q, Pintilie GD, Foulds CE, Lanz RB, Ludtke SJ, Schmid MF, Chiu W, O'Malley BW
Mol Cell (2015) 57 pp. 1047-1058 [ Pubmed: 25728767 DOI: doi:10.1016/j.molcel.2015.01.025 ]
- P300 bound to antibody 2 (400 kDa, Sample)
- Antibody 2 (Protein from unidentified)
- Histone acetyltransferase p300 (300 kDa, Protein from Homo sapiens)