Myo-inositol-1-phosphate synthase from Thermochaetoides thermophila in complex with NAD
Trager TK, Kyrilis FL, Hamdi F, Tuting C, Alfes M, Hofmann T, Schmidt C, Kastritis PL
PNAS (2024) 121 pp. e2400912121-e2400912121 [ DOI: doi:10.1073/pnas.2400912121 Pubmed: 39145930 ]
Cryo-EM snapshots of Eukaryotic Membrane Proteins in Native Lipid-Bilayer Nanodiscs
Janson K, Kyrilis FL, Tüting C, Alfes M, Das M, Träger TK, Schmidt C, Hamdi F, Vargas C, Keller S, Meister A, Kastritis PL
Biomacromolecules (2022) 23 pp. 5084-5094 [ DOI: 10.1021/acs.biomac.2c00935 Pubmed: 36399657 ]
Image sets:
Cryo-EM Snapshots of Nanodisc-Embedded Native Eukaryotic Membrane Proteins
Janson K, Kyrilis FL, Tuting C, Alfes M, Das M, Trager TK, Schmidt C, Hamdi F, Vargas C, Keller S, Meister A, Kastritis PL
Biomacromolecules (2022) 23 pp. 5084-5094 [ DOI: doi:10.1021/acs.biomac.2c00935 Pubmed: 36399657 ]
myo-Inositol-1-Phosphate Synthase
Janson K, Kyrilis FL, Tuting C, Alfes M, Das M, Trager TK, Schmidt C, Hamdi F, Vargas C, Keller S, Meister A, Kastritis PL
Biomacromolecules (2022) 23 pp. 5084-5094 [ DOI: doi:10.1021/acs.biomac.2c00935 Pubmed: 36399657 ]
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.4 Å
EM Method: Single-particle
Fitted PDBs: 6r6h
Q-score: 0.146
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Eloc_human (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (34 kDa, Protein from Homo sapiens)
- Rbx1_human (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-ring e3 ligases (crls) complexes with neddylated cop9 signalosome (csn) (Complex from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (17 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7f
Q-score: 0.001
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Ternary complex of cop9 signalosome (csn) and neddylated cullin-ring e3 ligase crl (cullin-2 with rbx1, elongin-b, elongin-c and vhl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6r7h
Q-score: 0.05
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn1-csn8) with cullin-ring e3 ligase deneddylated cullin-2, rbx1, elongin-b and elonginc (Complex from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (48 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cullin-2 (76 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6r7i
Q-score: 0.148
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Zinc ion (65 Da, Ligand)
- Elongin-c (11 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (52 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Csn-crl2-n8 (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Elongin-b (11 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6r7n
Q-score: 0.136
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cns (cop9 signalosome) with csn5/csn6 the catalytic heterodimer complexed with cul2 (cul2, elonginb, elongingc, rbx1 and vdl) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Rbx1 e3 ubiquitin-protein ligase (10 kDa, Protein from Homo sapiens)
- Csn7b_human (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
core of the human pyruvate dehydrogenase
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 6h55
Q-score: 0.315
Prajapati S, Haselbach D, Wittig S, Patel MS, Chari A, Schmidt C, Stark H, Tittmann K
Structure (2019) 27 pp. 1124-1136.e4 [ DOI: doi:10.1016/j.str.2019.04.009 Pubmed: 31130485 ]