Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.4 Å
EM Method: Single-particle
Fitted PDBs: 6r6h
Q-score: 0.146
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (34 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (17 kDa, Protein from Homo sapiens)
- Eloc_human (11 kDa, Protein from Homo sapiens)
- Rbx1_human (10 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Cullin-ring e3 ligases (crls) complexes with neddylated cop9 signalosome (csn) (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7f
Q-score: 0.001
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn) and neddylated cullin-ring e3 ligase crl (cullin-2 with rbx1, elongin-b, elongin-c and vhl) (Complex from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (13 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Von hippel-lindau disease tumor suppressor (18 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 8.8 Å
EM Method: Single-particle
Fitted PDBs: 6r7h
Q-score: 0.05
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 5 (35 kDa, Protein from Homo sapiens)
- Cullin-2 (76 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (49 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 2 (48 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 6 (32 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Ternary complex of cop9 signalosome (csn1-csn8) with cullin-ring e3 ligase deneddylated cullin-2, rbx1, elongin-b and elonginc (Complex from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 5.9 Å
EM Method: Single-particle
Fitted PDBs: 6r7i
Q-score: 0.148
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (23 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- E3 ubiquitin-protein ligase rbx1 (10 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Elongin-c (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cop9 signalosome complex subunit 6 (36 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 5 (37 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (52 kDa, Protein from Homo sapiens)
- Csn-crl2-n8 (Complex from Homo sapiens)
- Nedd8 (8 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 7b (23 kDa, Protein from Homo sapiens)
Structural basis of Cullin-2 RING E3 ligase regulation by the COP9 signalosome
Resolution: 6.5 Å
EM Method: Single-particle
Fitted PDBs: 6r7n
Q-score: 0.136
Faull SV, Lau AMC, Martens C, Ahdash Z, Hansen K, Yebenes H, Schmidt C, Beuron F, Cronin NB, Morris EP, Politis A
Nat Commun (2019) 10 pp. 3814-3814 [ Pubmed: 31444342 DOI: doi:10.1038/s41467-019-11772-y ]
- Cop9 signalosome complex subunit 2 (51 kDa, Protein from Homo sapiens)
- Cullin-2 (87 kDa, Protein from Homo sapiens)
- Csn7b_human (23 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 1 (55 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 3 (45 kDa, Protein from Homo sapiens)
- Zinc ion (65 Da, Ligand)
- Cns (cop9 signalosome) with csn5/csn6 the catalytic heterodimer complexed with cul2 (cul2, elonginb, elongingc, rbx1 and vdl) (Complex from Homo sapiens)
- Elongin-b (11 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 4 (46 kDa, Protein from Homo sapiens)
- Rbx1 e3 ubiquitin-protein ligase (10 kDa, Protein from Homo sapiens)
- Elongin-c (12 kDa, Protein from Homo sapiens)
- Cop9 signalosome complex subunit 8 (22 kDa, Protein from Homo sapiens)
core of the human pyruvate dehydrogenase
Resolution: 6.0 Å
EM Method: Single-particle
Fitted PDBs: 6h55
Q-score: 0.315
Prajapati S, Haselbach D, Wittig S, Patel MS, Chari A, Schmidt C, Stark H, Tittmann K
Structure (2019) 27 pp. 1124-1136.e4 [ DOI: doi:10.1016/j.str.2019.04.009 Pubmed: 31130485 ]
Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 5mc6
Q-score: 0.362
Schmidt C, Kowalinski E, Shanmuganathan V, Defenouillere Q, Braunger K, Heuer A, Pech M, Namane A, Berninghausen O, Fromont-Racine M, Jacquier A, Conti E, Becker T, Beckmann R
Science (2016) 354 pp. 1431-1433 [ DOI: doi:10.1126/science.aaf7520 Pubmed: 27980209 ]
- 60s ribosomal protein l43-a (10 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l10 (25 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s11-a (17 kDa, Protein from Baker's yeast)
- A-site trna (24 kDa, RNA from Baker's yeast)
- 60s ribosomal protein l21-a (18 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l5 (33 kDa, Protein from Baker's yeast)
- Eukaryotic translation initiation factor 5a-1 (17 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l35-a (13 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s5 (25 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l20-a (20 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s29-a (6 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s27-a (8 kDa, Protein from Baker's yeast)
- 18s ribosomal rna (579 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 60s ribosomal protein l9-a (21 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l25 (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l30 (11 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l28 (16 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s23-a (16 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l18-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l17-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l33-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s4-a (29 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l31-a (12 kDa, Protein from Baker's yeast)
- 5.8s ribosomal rna (50 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- Native ribosome-ski2-ski3-ski8 complex from s. cerevisiae (3 MDa, Complex from Saccharomyces cerevisiae)
- 60s ribosomal protein l6-a (20 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l38 (8 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l37-a (9 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l16-a (22 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l2-a (27 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s8-a (22 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s13 (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s9-a (22 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l8-a (28 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l22-a (13 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s17-b (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l24-a (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s28-b (7 kDa, Protein from Baker's yeast)
- Ul1 (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s25-a (12 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l3 (43 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l19-a (21 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s10-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s14-a (14 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l11-a (19 kDa, Protein from Baker's yeast)
- P-site trna (24 kDa, RNA from Baker's yeast)
- 60s ribosomal protein l7-a (27 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l32 (14 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l4-a (39 kDa, Protein from Baker's yeast)
- Antiviral helicase ski2 (146 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s7-a (21 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s0-a (28 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l15-a (24 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l39 (6 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l23-a (14 kDa, Protein from Baker's yeast)
- Guanine nucleotide-binding protein subunit beta-like protein (34 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l26-a (14 kDa, Protein from Baker's yeast)
- Mrna (10 kDa, RNA from Baker's yeast)
- 40s ribosomal protein s3 (26 kDa, Protein from Baker's yeast)
- 5s ribosomal rna (38 kDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 40s ribosomal protein s21-a (9 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l41-a (3 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l36-a (11 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s26-a (13 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s24-a (15 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l14-a (15 kDa, Protein from Baker's yeast)
- Superkiller protein 3 (163 kDa, Protein from Baker's yeast)
- Ubiquitin-60s ribosomal protein l40 (14 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s18-a (17 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l29 (6 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l13-a (22 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l42-a (12 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s1-a (28 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s2 (27 kDa, Protein from Baker's yeast)
- Ubiquitin-40s ribosomal protein s31 (17 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s22-a (14 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l27-a (15 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s15 (16 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s30-a (7 kDa, Protein from Baker's yeast)
- Antiviral protein ski8 (44 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s19-a (15 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s16-a (15 kDa, Protein from Baker's yeast)
- 25s ribosomal rna (1 MDa, RNA from Saccharomyces cerevisiae (strain ATCC 204508 / S288c))
- 40s ribosomal protein s12 (15 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s6-a (27 kDa, Protein from Baker's yeast)
- 40s ribosomal protein s20 (13 kDa, Protein from Baker's yeast)
- 60s ribosomal protein l34-a (13 kDa, Protein from Baker's yeast)