Modifying portion of human FASN with NADPH and the ACP at the ER domain
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Fatty acid synthase (279 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Modifying portion of human FASN with NADPH and the ACP at the DH domain
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Fatty acid synthase (279 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 1
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 2
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 3
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 4
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 5
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 8
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 7
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)
Composite structure of human FASN with NADPH in State 6
Schultz K, Costa-Pinheiro P, Gardner L, Pinheiro LV, Ramirez-Solis J, Gardner SM, Wellen KE, Marmorstein R
Nature (2025) [ Pubmed: 39979457 DOI: doi:10.1038/s41586-025-08587-x ]
- Fatty acid synthase (278 kDa, Protein from Homo sapiens)
- Human fatty acid synthase (554 kDa, Complex from Homo sapiens)
- Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate (745 Da, Ligand)