Cryo-EM Structure of disulfide stabilized HMPV F v4-B
Resolution: 3.23 Å
EM Method: Single-particle
Fitted PDBs: 7lze
Q-score: 0.528
Stewart-Jones GBE, Gorman J, Ou L, Zhang B, Joyce MG, Yang L, Cheng C, Chuang GY, Foulds KE, Kong WP, Olia AS, Sastry M, Shen CH, Todd JP, Tsybovsky Y, Verardi R, Yang Y, Collins PL, Corti D, Lanzavecchia A, Scorpio DG, Mascola JR, Buchholz UJ, Kwong PD
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2106196118 Pubmed: 34551978 ]
- Fusion glycoprotein f0 (54 kDa, Protein from Human metapneumovirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Hmpv f v4-b (Complex from Human metapneumovirus)
HMPV F v3-B in complex with MPE33 Fab
Stewart-Jones GBE, Gorman J, Ou L, Zhang B, Joyce MG, Yang L, Cheng C, Chuang GY, Foulds KE, Kong WP, Olia AS, Sastry M, Shen CH, Todd JP, Tsybovsky Y, Verardi R, Yang Y, Collins PL, Corti D, Lanzavecchia A, Scorpio DG, Mascola JR, Buchholz UJ, Kwong PD
PNAS (2021) 118 [ DOI: doi:10.1073/pnas.2106196118 Pubmed: 34551978 ]
- Hmpv f v3-b (Complex from Human metapneumovirus)
- Mpe33 heavy chain (Protein from Homo sapiens)
- Hmpv f v3-b in complex with mpe33 (Complex)
- Mpe33 (Complex from Homo sapiens)
- Hmpv f v3-b (Protein from Human metapneumovirus)
- Mpe33 light chain (Protein from Homo sapiens)
Cryo-EM structure of Human Parainfluenza Virus Type 3 (hPIV3) in complex with antibody PIA174
Resolution: 4.3 Å
EM Method: Single-particle
Fitted PDBs: 6mjz
Q-score: 0.282
Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD
PNAS (2018) 115 pp. 12265-12270 [ Pubmed: 30420505 DOI: doi:10.1073/pnas.1811980115 ]
- Pia174 fab heavy chain (23 kDa, Protein from Homo sapiens)
- Complex of hpiv3 env q162c-l168c, i213c-g230c, a463v, i474y in complex with antibody pia174 (Complex from Human respirovirus 3)
- Fusion glycoprotein f0 (54 kDa, Protein from Human parainfluenza virus 3)
- Pia174 fab light chain (22 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 6cde
Q-score: 0.443
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Vfp20.01 light chain (23 kDa, Protein from Homo sapiens)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 light chain (23 kDa, Protein from Homo sapiens)
- Alpha-d-mannopyranose (180 Da, Ligand)
- Glycoprotein 41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 light chain (22 kDa, Protein from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Vfp20.01 heavy chain (22 kDa, Protein from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vfp20.01 (Complex from Homo sapiens)
- Pgt122 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 6cdi
Q-score: 0.432
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Pgt122 light chain (11 kDa, Protein from Homo sapiens)
- Vfp16.02 heavy chain (22 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Pgt122 heavy chain (14 kDa, Protein from Homo sapiens)
- Vrc03 light chain (11 kDa, Protein from Homo sapiens)
- Vfp20.01-bg505 ds-sosip-vrc03-pgt122 (Complex)
- Glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Vfp16.02 (Complex from Homo sapiens)
- Glycoprotein 120 (52 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 (Complex from Homo sapiens)
- Vfp16.02 light chain (23 kDa, Protein from Homo sapiens)
- Glycoprotein (Complex from Human immunodeficiency virus 1)
- Vrc03 heavy chain (24 kDa, Protein from Homo sapiens)
- Vrc03 (Complex from Homo sapiens)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
- Bg505 ds-sosip (Protein from Human immunodeficiency virus 1)
- Hiv-1 env trimer in complex with antibody (Complex from Human immunodeficiency virus 1)
- Vfp1.01 light chain (Protein from Homo sapiens)
- Hiv-1 env trimer (Complex from Human immunodeficiency virus 1)
- Vfp1.01 heavy chain (Protein from Homo sapiens)
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]
Xu K, Acharya P, Kong R, Cheng C, Chuang GY, Liu K, Louder MK, O'Dell S, Rawi R, Sastry M, Shen CH, Zhang B, Zhou T, Asokan M, Bailer RT, Chambers M, Chen X, Choi CW, Dandey VP, Doria-Rose NA, Druz A, Eng ET, Farney SK, Foulds KE, Geng H, Georgiev IS, Gorman J, Hill KR, Jafari AJ, Kwon YD, Lai YT, Lemmin T, McKee K, Ohr TY, Ou L, Peng D, Rowshan AP, Sheng Z, Todd JP, Tsybovsky Y, Viox EG, Wang Y, Wei H, Yang Y, Zhou AF, Chen R, Yang L, Scorpio DG, McDermott AB, Shapiro L, Carragher B, Potter CS, Mascola JR, Kwong PD
Nat Med (2018) 24 pp. 857-867 [ Pubmed: 29867235 DOI: doi:10.1038/s41591-018-0042-6 ]