Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 8szg
Q-score: 0.491
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ DOI: doi:10.1038/s41586-024-07055-2 Pubmed: 38326620 ]
- Phosphate ion (94 Da, Ligand)
- Water (18 Da, Ligand)
- Spermine (202 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(q) subunit alpha (41 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Extracellular calcium-sensing receptor (123 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cinacalcet-bound human calcium-sensing receptor casr-gq complex in lipid nanodiscs (Complex from Homo sapiens)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8szh
Q-score: 0.572
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ DOI: doi:10.1038/s41586-024-07055-2 Pubmed: 38326620 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Water (18 Da, Ligand)
- Spermine (202 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Cinacalcet-bound human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
- Extracellular calcium-sensing receptor (99 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- N-[(1r)-1-(naphthalen-1-yl)ethyl]-3-[3-(trifluoromethyl)phenyl]propan-1-amine (357 Da, Ligand)
Cryo-EM structure of PAM-free human calcium-sensing receptor CaSR-Gi complex in lipid nanodiscs
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8szi
Q-score: 0.51
He F, Wu CG, Gao Y, Rahman SN, Zaoralova M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G
Nature (2024) 626 pp. 1141-1148 [ DOI: doi:10.1038/s41586-024-07055-2 Pubmed: 38326620 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Phosphate ion (94 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Tryptophan (204 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Extracellular calcium-sensing receptor (108 kDa, Protein from Homo sapiens)
- 1,2-dioleoyl-sn-glycero-3-phosphocholine (787 Da, Ligand)
- Extracellular calcium-sensing receptor (105 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Pam-free human calcium-sensing receptor casr-gi complex in lipid nanodiscs (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM Structure of mGlu2 - Gi Complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mts
Q-score: 0.54
Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 450-454 [ DOI: doi:10.1038/s41586-021-03680-3 Pubmed: 34194039 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Mglu2 - heterotrimeric gi complex (277 kDa, Complex from Homo sapiens)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- 2-methoxy-6-propyl-n-(2-{4-[(1h-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine (425 Da, Ligand)
Structure of the Visual Signaling Complex between Transducin and Phosphodiesterase 6
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7jsn
Q-score: 0.506
Gao Y, Eskici G, Ramachandran S, Poitevin F, Seven AB, Panova O, Skiniotis G, Cerione RA
Mol Cell (2020) 80 pp. 237- [ DOI: doi:10.1016/j.molcel.2020.09.013 Pubmed: 33007200 ]
- Rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha (e.c.3.1.4.35), rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit beta (e.c.3.1.4.35), retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (e.c.3.1.4.35) (Complex from Bos taurus)
- Magnesium ion (24 Da, Ligand)
- Guanosine-3',5'-monophosphate (345 Da, Ligand)
- Rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit beta (98 kDa, Protein from Bos taurus)
- Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (9 kDa, Protein from Bos taurus)
- Guanine nucleotide-binding protein g(t) subunit alpha-1, guanine nucleotide-binding protein g(i) subunit alpha-1 chimera (42 kDa, Protein from Bos taurus)
- Complex of transducin and phosphodiesterase 6 (300 kDa, Complex)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Guanine nucleotide-binding protein g(t) subunit alpha-1, guanine nucleotide-binding protein g(i) subunit alpha-1 chimera,gt-alpha/gi1-alpha chimera (Complex from Bos taurus)
- Rod cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha (99 kDa, Protein from Bos taurus)
- 2-{2-ethoxy-5-[(4-ethylpiperazin-1-yl)sulfonyl]phenyl}-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1h)-one (488 Da, Ligand)