Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 7ran
Q-score: 0.49
Kaplan AL, Confair DN, Kim K, Barros-Alvarez X, Rodriguiz RM, Yang Y, Kweon OS, Che T, McCorvy JD, Kamber DN, Phelan JP, Martins LC, Pogorelov VM, DiBerto JF, Slocum ST, Huang XP, Kumar JM, Robertson MJ, Panova O, Seven AB, Wetsel AQ, Wetsel WC, Irwin JJ, Skiniotis G, Shoichet BK, Roth BL, Ellman JA
Nature (2022) 610 pp. 582-591 [ Pubmed: 36171289 DOI: doi:10.1038/s41586-022-05258-z ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 5-ht2ar bound to a tetrahydropyridine agonist (r-69) in complex with heterotrimeric mini-gq protein and single-chain variable fragment (scfv16) (Complex from Homo sapiens)
- Single-chain variable fragment 16 (scfv16) (30 kDa, Protein from Homo sapiens)
- G protein subunit q (gi2-mini-gq chimera) (28 kDa, Protein from Homo sapiens)
- 5-hydroxytryptamine receptor 2a (38 kDa, Protein from Homo sapiens)
- (3r)-3-methyl-5-(1h-pyrrolo[2,3-b]pyridin-3-yl)-1,2,3,6-tetrahydropyridin-1-ium (214 Da, Ligand)
LPHN3 (ADGRL3) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.9 Å
EM Method: Single-particle
Fitted PDBs: 7sf7
Q-score: 0.479
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ Pubmed: 35418682 DOI: doi:10.1038/s41586-022-04575-7 ]
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Latrophilin 3 (adgrl3) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
- Isoform 1 of adhesion g protein-coupled receptor l3 (34 kDa, Protein from Homo sapiens)
GPR56 (ADGRG1) 7TM domain bound to tethered agonist in complex with G protein heterotrimer
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7sf8
Q-score: 0.544
Barros-Alvarez X, Nwokonko RM, Vizurraga A, Matzov D, He F, Papasergi-Scott MM, Robertson MJ, Panova O, Yardeni EH, Seven AB, Kwarcinski FE, Su H, Peroto MC, Meyerowitz JG, Shalev-Benami M, Tall GG, Skiniotis G
Nature (2022) 604 pp. 757-762 [ Pubmed: 35418682 DOI: doi:10.1038/s41586-022-04575-7 ]
- Isoform 2 of adhesion g-protein coupled receptor g1 (34 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- G protein subunit 13 (gi2-mini-g13 chimera) (26 kDa, Protein from Homo sapiens)
- Gpr56 (adgrg1) 7tm domain bound to tethered agonist in complex with mini-g13 protein (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
CryoEM Structure of Full-Length mGlu2 in Inactive-State Bound to Antagonist LY341495
Resolution: 3.65 Å
EM Method: Single-particle
Fitted PDBs: 7mtq
Q-score: 0.39
Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 450-454 [ DOI: doi:10.1038/s41586-021-03680-3 Pubmed: 34194039 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- 2-[(1s,2s)-2-carboxycyclopropyl]-3-(9h-xanthen-9-yl)-d-alanine (353 Da, Ligand)
- Full-length mglu2 in inactive-state (191 kDa, Complex from Homo sapiens)
CryoEM Structure of Full-Length mGlu2 Bound to Ago-PAM ADX55164 and Glutamate
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7mtr
Q-score: 0.427
Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 450-454 [ DOI: doi:10.1038/s41586-021-03680-3 Pubmed: 34194039 ]
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- Full-length mglu2 in ago-pam and l-glutamate bound-state (191 kDa, Complex from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2-methoxy-6-propyl-n-(2-{4-[(1h-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine (425 Da, Ligand)
CryoEM Structure of mGlu2 - Gi Complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7mts
Q-score: 0.54
Seven AB, Barros-Alvarez X, de Lapeyriere M, Papasergi-Scott MM, Robertson MJ, Zhang C, Nwokonko RM, Gao Y, Meyerowitz JG, Rocher JP, Schelshorn D, Kobilka BK, Mathiesen JM, Skiniotis G
Nature (2021) 595 pp. 450-454 [ DOI: doi:10.1038/s41586-021-03680-3 Pubmed: 34194039 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Mglu2 - heterotrimeric gi complex (277 kDa, Complex from Homo sapiens)
- Metabotropic glutamate receptor 2 (93 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Glutamic acid (147 Da, Ligand)
- 2-methoxy-6-propyl-n-(2-{4-[(1h-tetrazol-5-yl)methoxy]phenyl}ethyl)thieno[2,3-d]pyrimidin-4-amine (425 Da, Ligand)