Cryo-EM map of DH851.3 bound to HIV-1 CH505 Env
Resolution: 5.6 Å
EM Method: Single-particle
Fitted PDBs: 7lu9
Q-score: 0.22
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Dh851.3 bound to hiv-1 ch505 env (Complex from Human immunodeficiency virus 1)
- Dh851.3 heavy chain (23 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp120 (51 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 light chain (21 kDa, Protein from Macaca mulatta)
- Dh851.3 heavy chain (24 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Dh851.3 light chain (22 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Manne K, Stalls V, Hsu AL, Borgnia MJ, Stewart-Jones G, Lee MS, Bronkema N, Perfect J, Moody MA, Wiehe K, Bradley T, Kepler TB, Alam SM, Foulger A, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelso G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
bioRxiv (2020) https://doi.org/10.1101/2020.06.30.178921 [ DOI: doi:10.1101/2020.06.30.178921 ]
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) light chain (Protein from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fab-dimer bound near the cd4 binding site of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 (Protein from Human immunodeficiency virus 1)
- Antibody dh898.1 fragment antigen binding (fab) dimer (Complex from Macaca mulatta)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (94 kDa, Complex)
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Dh898.1 fab light chain (Protein from Macaca mulatta)
- Dh898.1 fab heavy chain (Protein from Macaca mulatta)
- Antibody dh898.1 fragment antigen binding (fab) dimer (94 kDa, Complex from Macaca mulatta)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (210 kDa, Complex from Human immunodeficiency virus 1)
- Antibody dh898.1 fab-dimer bound to glycans 332, 392, and 396 of hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 trimer (304 kDa, Complex)
Cryo-electron microcospy reconstruction of CH848.3.D0949.10.17chim.6R.DS.SOSIP.664 HIV Env
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 7l6o
Q-score: 0.426
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp120 (Protein from Human immunodeficiency virus 1)
- Ch848.3.d0949.10.17chim.6r.ds.sosip.664 - gp41 (Protein from Human immunodeficiency virus 1)
- Hiv env ch848.3.d0949.10.17chim.6r.ds.sosip.664 unliganded trimer in the presence of but not bound to dh898.1 fab (209 kDa, Complex from Human immunodeficiency virus 1)
Cryo-electron microscopy reconstruction of locally refined antibody DH898.1 Fab-dimer
Resolution: 4.8 Å
EM Method: Single-particle
Fitted PDBs: 7l6m
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955-2972.e25 [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7l02
Q-score: 0.341
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 2g12 (Complex)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7l06
Q-score: 0.303
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 2g12 (Complex from Homo sapiens)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7l09
Q-score: 0.365
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ DOI: doi:10.1016/j.cell.2021.04.042 Pubmed: 34019795 ]
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Antibody 2g12 (Complex from Homo sapiens)