Saunders KO, Edwards RJ, Tilahun K, Manne K, Lu X, Cain DW, Wiehe K, Williams WB, Mansouri K, Hernandez GE, Sutherland L, Scearce R, Parks R, Barr M, DeMarco T, Eater CM, Eaton A, Morton G, Mildenberg B, Wang Y, Rountree RW, Tomai MA, Fox CB, Moody MA, Alam SM, Santra S, Lewis MG, Denny TN, Shaw GM, Montefiori DC, Acharya P, Haynes BF
Sci Transl Med (2022) 14 pp. eabo5598-eabo5598 [ Pubmed: 36070369 DOI: doi:10.1126/scitranslmed.abo5598 ]
- Complex of hiv env ch505tfchim.6r.sosip.664.v4.1 with dh950 antibody fab (23 kDa, Complex from Human immunodeficiency virus 2)
- Dh950 antibody fab heavy chain (Protein from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 trimer (Complex from Human immunodeficiency virus 2)
- Dh950 antibody fab heavy chain (Complex from Homo sapiens)
- Dh950 antibody fab light chain (Complex from Homo sapiens)
- Dh950 antibody fab light chain (Protein from Homo sapiens)
- Hiv env ch505tfchim.6r.sosip.664.v4.1 (Protein from Human immunodeficiency virus 1)
- Dh950 antibody fab (Complex from Homo sapiens)
Cryo-EM map of DH898.1 Fab-dimer bound near the CD4 binding site of HIV-1 Env CH848 SOSIP trimer
Resolution: 4.7 Å
EM Method: Single-particle
Fitted PDBs: 7lua
Q-score: 0.267
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Ch848 sosip gp120 (52 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Env polyprotein (16 kDa, Protein from Simian-Human immunodeficiency virus)
- Cryo-em structure of dh898.1 fab-dimer bound near the cd4 binding site of hiv-1 env ch848 sosip trimer. (Complex from Human immunodeficiency virus 1)
- Dh898.1 heavy chain (23 kDa, Protein from Homo sapiens)
- Dh898.1 light chain (23 kDa, Protein from Homo sapiens)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to one copy of domain-swapped antibody 2G12
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7l02
Q-score: 0.341
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex)
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex from Severe acute respiratory syndrome-related coronavirus)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of SARS-CoV-2 2P S ectodomain bound to two copies of domain-swapped antibody 2G12
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7l06
Q-score: 0.303
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7l09
Q-score: 0.365
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF
Cell (2021) 184 pp. 2955- [ Pubmed: 34019795 DOI: doi:10.1016/j.cell.2021.04.042 ]
- Severe acute respiratory syndrome-related coronavirus spike glycoprotein in complex with domain-swapped antibody 2g12 (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- 2g12 heavy chain (23 kDa, Protein from Homo sapiens)
- Antibody 2g12 (Complex from Homo sapiens)
- 2g12 light chain (23 kDa, Protein from Homo sapiens)
- Spike glycoprotein (124 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome-related coronavirus)
BG505 SOSIP.664 HIV-1 Env trimer in complex with anti-HIV CH235.12 wk323 Fab
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Cell (2016) 165 pp. 449-463 [ Pubmed: 26949186 DOI: doi:10.1016/j.cell.2016.02.022 ]
B41 SOSIP.664 HIV-1 Env trimer in complex with anti-HIV CH235.12 wk323 Fab
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Cell (2016) 165 pp. 449-463 [ Pubmed: 26949186 DOI: doi:10.1016/j.cell.2016.02.022 ]
B41 SOSIP.664 HIV-1 Env trimer in complex with anti-HIV CH235.9 wk152 Fab
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Cell (2016) 165 pp. 449-463 [ Pubmed: 26949186 DOI: doi:10.1016/j.cell.2016.02.022 ]
BG505 SOSIP.664 HIV-1 Env trimer in complex with anti-HIV CH235.9 wk152 Fab
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Cell (2016) 165 pp. 449-463 [ Pubmed: 26949186 DOI: doi:10.1016/j.cell.2016.02.022 ]
BG505 SOSIP.664 HIV-1 Env trimer in complex with anti-HIV CH235 wk41 Fab
Bonsignori M, Zhou T, Sheng Z, Chen L, Gao F, Joyce MG, Ozorowski G, Chuang GY, Schramm CA, Wiehe K, Alam SM, Bradley T, Gladden MA, Hwang KK, Iyengar S, Kumar A, Lu X, Luo K, Mangiapani MC, Parks RJ, Song H, Acharya P, Bailer RT, Cao A, Druz A, Georgiev IS, Kwon YD, Louder MK, Zhang B, Zheng A, Hill BJ, Kong R, Soto C, Mullikin JC, Douek DC, Montefiori DC, Moody MA, Shaw GM, Hahn BH, Kelsoe G, Hraber PT, Korber BT, Boyd SD, Fire AZ, Kepler TB, Shapiro L, Ward AB, Mascola JR, Liao HX, Kwong PD, Haynes BF
Cell (2016) 165 pp. 449-463 [ Pubmed: 26949186 DOI: doi:10.1016/j.cell.2016.02.022 ]