Structure of human SIT1 (focussed map / refinement)
Resolution: 3.76 Å
EM Method: Single-particle
Fitted PDBs: 8p2w
Q-score: 0.408
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
Structure of human SIT1:ACE2 complex (open PD conformation)
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8p2x
Q-score: 0.361
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human SIT1:ACE2 complex (closed PD conformation)
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8p2y
Q-score: 0.368
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human SIT1 bound to L-pipecolate (focussed map / refinement)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 8p2z
Q-score: 0.481
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- (2s)-piperidine-2-carboxylic acid (129 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human SIT1:ACE2 complex (open PD conformation) bound to L-pipecolate
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8p30
Q-score: 0.414
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- (2s)-piperidine-2-carboxylic acid (129 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of human SIT1:ACE2 complex (closed PD conformation) bound to L-pipecolate
Resolution: 3.24 Å
EM Method: Single-particle
Fitted PDBs: 8p31
Q-score: 0.415
Li HZ, Pike ACW, Lotsaris I, Chi G, Hansen JS, Lee SC, Rodstrom KEJ, Bushell SR, Speedman D, Evans A, Wang D, He D, Shrestha L, Nasrallah C, Burgess-Brown NA, Vandenberg RJ, Dafforn TR, Carpenter EP, Sauer DB
Nat Commun (2024) 15 pp. 5503-5503 [ Pubmed: 38951531 DOI: doi:10.1038/s41467-024-48921-x ]
- Processed angiotensin-converting enzyme 2 (93 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-alpha-d-glucopyranose (221 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Sit1:ace2 complex (340 kDa, Complex from Homo sapiens)
- (2s)-piperidine-2-carboxylic acid (129 Da, Ligand)
- Sodium- and chloride-dependent transporter xtrp3 (71 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Undecyl-maltoside (496 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Calcium ion (40 Da, Ligand)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ Pubmed: 31477691 DOI: doi:10.1038/s41467-019-11753-1 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)