Cryo-EM structure of the inner MKLN1 dimer from an autoinhibited MKLN1 tetramer
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8ttq
Q-score: 0.398
Barbulescu P, Chana CK, Wong MK, Ben Makhlouf I, Bruce JP, Feng Y, Keszei AFA, Wong C, Mohamad-Ramshan R, McGary LC, Kashem MA, Ceccarelli DF, Orlicky S, Fang Y, Kuang H, Mazhab-Jafari M, Pezo RC, Bhagwat AS, Pugh TJ, Gingras AC, Sicheri F, Martin A
Nat Commun (2024) 15 pp. 7541-7541 [ DOI: doi:10.1038/s41467-024-52009-x Pubmed: 39215025 ]
CryoEM structure of the HisRS-like domain of human GCN2
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8t7t
Q-score: 0.45
Yin JZ, Keszei AFA, Houliston S, Filandr F, Beenstock J, Daou S, Kitaygorodsky J, Schriemer DC, Mazhab-Jafari MT, Gingras AC, Sicheri F
Structure (2024) 32 pp. 795-811.e6 [ Pubmed: 38531363 DOI: doi:10.1016/j.str.2024.02.021 ]
- Eif-2-alpha kinase gcn2 (187 kDa, Protein from Homo sapiens)
- Dimeric hisrs-like domain of human gcn2 (Complex from Homo sapiens)
Cryo-EM structure of the RAF activating complex KSR-MEK-CNK-HYP
Resolution: 3.32 Å
EM Method: Single-particle
Fitted PDBs: 8bw9
Q-score: 0.468
Maisonneuve P, Sahmi M, Bergeron-Labrecque F, Ma XI, Queguiner J, Arseneault G, Lefrancois M, Kurinov I, Fronzes R, Sicheri F, Therrien M
Nat Struct Mol Biol (2024) 31 pp. 1028-1038 [ DOI: doi:10.1038/s41594-024-01233-6 Pubmed: 38388830 ]
- Magnesium ion (24 Da, Ligand)
- Phosphoaminophosphonic acid-adenylate ester (506 Da, Ligand)
- Connector enhancer of ksr protein cnk (38 kDa, Protein from Drosophila melanogaster)
- Dual specificity mitogen-activated protein kinase kinase dsor1 (43 kDa, Protein from Drosophila melanogaster)
- Protein aveugle (13 kDa, Protein from Drosophila melanogaster)
- Trametinib (615 Da, Ligand)
- Ksr (36 kDa, Protein from Drosophila melanogaster)
- Quaternary complex of the kinase domains of ksr and mek bound to the scaffolding complex cnk-hyp (132 kDa, Complex from Drosophila melanogaster)
Structural model of 53BP1 bound to a ubiquitylated and methylated nucleosome, at 4.5 A resolution
Resolution: 4.54 Å
EM Method: Single-particle
Fitted PDBs: 5kgf
Q-score: 0.301
Wilson MD, Benlekbir S, Fradet-Turcotte A, Sherker A, Julien JP, McEwan A, Noordermeer SM, Sicheri F, Rubinstein JL, Durocher D
Nature (2016) 536 pp. 100-103 [ Pubmed: 27462807 DOI: doi:10.1038/nature18951 ]
- Histone h4 (11 kDa, Protein from Xenopus laevis)
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Histone h3.2 (15 kDa, Protein from Xenopus laevis)
- Histone h2b.1 (Complex from Homo sapiens)
- Ubiquitylated methylated histone octamer (138 kDa, Complex from unclassified)
- Ubiquitin (Complex from Homo sapiens)
- Histone h2a type 1 (14 kDa, Protein from Homo sapiens)
- Widom-601 dna (882 kDa, Complex from synthetic construct)
- Dna (145-mer) (44 kDa, DNA from synthetic construct)
- Ubiquitin (8 kDa, Protein from Homo sapiens)
- Histone h4kc20me2 (Complex from Xenopus laevis)
- Histone h2a.1 k13rk36r (Complex from Homo sapiens)
- Gst-53bp1 (89 kDa, Complex from Homo sapiens)
- Tumor suppressor p53-binding protein 1 (2 kDa, Protein from Homo sapiens)
- Ncp-ubme/gst-53bp1 complex (318 kDa, Complex)
- Histone h2b type 1-c/e/f/g/i (13 kDa, Protein from Homo sapiens)
- Histone h3 (Complex from Xenopus laevis)
- Ncp-ubme (226 kDa, Complex from unclassified)