Structure of PDE6C without inhibitory p gamma
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ DOI: doi:10.1073/pnas.2419732121 Pubmed: 39739818 ]
- Pde6c (Protein from Homo sapiens)
- Cone pde6 (218 kDa, Complex from Homo sapiens)
Structure of PDE6C in complex with inhibitory cone p gamma in the presence of cGMP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9cxg
Q-score: 0.453
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ DOI: doi:10.1073/pnas.2419732121 Pubmed: 39739818 ]
- Zinc ion (65 Da, Ligand)
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Pde6c cone p gamma complex (218 kDa, Complex from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Cone p gamma (13 kDa, Protein from Homo sapiens)
- Guanosine-5'-monophosphate (363 Da, Ligand)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the presence of cGMP
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cxh
Q-score: 0.518
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ DOI: doi:10.1073/pnas.2419732121 Pubmed: 39739818 ]
- Zinc ion (65 Da, Ligand)
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (11 kDa, Protein from Bos taurus)
- Cone pde6 ion complex with rod p gamma (218 kDa, Complex from Homo sapiens)
- Cyclic guanosine monophosphate (345 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Guanosine-5'-monophosphate (363 Da, Ligand)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit in the absence of added cGMP
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9cxi
Q-score: 0.523
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ DOI: doi:10.1073/pnas.2419732121 Pubmed: 39739818 ]
- Zinc ion (65 Da, Ligand)
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Cone pde6 (218 kDa, Complex from Homo sapiens)
- Rod pg (11 kDa, Protein from Mus musculus)
- Magnesium ion (24 Da, Ligand)
- Cyclic guanosine monophosphate (345 Da, Ligand)
Structure of PDE6C in complex with the rod inhibitory p gamma subunit with disordered GafA region
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 9cxj
Q-score: 0.445
Singh S, Srivastava D, Boyd K, Artemyev NO
PNAS (2025) 122 pp. e2419732121-e2419732121 [ DOI: doi:10.1073/pnas.2419732121 Pubmed: 39739818 ]
- Zinc ion (65 Da, Ligand)
- Cone cgmp-specific 3',5'-cyclic phosphodiesterase subunit alpha' (97 kDa, Protein from Homo sapiens)
- Retinal rod rhodopsin-sensitive cgmp 3',5'-cyclic phosphodiesterase subunit gamma (11 kDa, Protein from Bos taurus)
- Cone pde6c in complex with rod p gamma (218 kDa, Complex from Homo sapiens)
- Magnesium ion (24 Da, Ligand)
Cryo-EM structure of XCR1 signaling complex
Resolution: 3.07 Å
EM Method: Single-particle
Fitted PDBs: 9ast
Q-score: 0.455
Zhang X, Schlimgen RR, Singh S, Tomani MP, Volkman BF, Zhang C
PNAS (2024) 121 pp. e2405732121-e2405732121 [ DOI: doi:10.1073/pnas.2405732121 Pubmed: 39565315 ]
- Lymphotactin (13 kDa, Protein from Homo sapiens)
- Xcl1-xcr1-gi complex (Complex from Spodoptera frugiperda)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Chemokine xc receptor 1,non structural polyprotein (60 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (28 kDa, Protein from Mus musculus)
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)
Wang C, Yang Z, Loughlin BJ, Xu H, Veit G, Vorobiev S, Clarke OB, Jiang F, Li Y, Singh S, Rich Z, Menten ER, Grassucci RA, Wang W, Mezzell A, Fu Z, Wong K, Wetmore DR, Sutton RB, Brouillette CG, Urbatsch IL, Kappes JC, Lukacs GL, Frank J, Hunt JF, Cohen BM
To Be Published
- Human cftr (Protein from Homo sapiens)
- Cystic fibrosis transmembrane conductance regulator(cftr) (160 kDa, Complex from Homo sapiens)