Cryo-EM structure of rat SLC22A6 in the apo state
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8bvr
Q-score: 0.414
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Phosphate ion (94 Da, Ligand)
- Solute carrier family 22 member 6 (Complex from Rattus norvegicus)
- Synthetic nanobody (sybody) (Complex from Synthetic construct)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- Oat1 (Complex)
Cryo-EM structure of rat SLC22A6 bound to tenofovir
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8bvs
Q-score: 0.402
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- [2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methylphosphonic acid (287 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
Cryo-EM structure of rat SLC22A6 bound to probenecid
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8bvt
Q-score: 0.364
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8bw7
Q-score: 0.389
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 2-oxoglutaric acid (146 Da, Ligand)
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state
Resolution: 3.43 Å
EM Method: Single-particle
Fitted PDBs: 8omu
Q-score: 0.411
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- Oat1 (Complex from Rattus norvegicus)