Cryo-EM structure of rat SLC22A6 in the apo state
Resolution: 3.52 Å
EM Method: Single-particle
Fitted PDBs: 8bvr
Q-score: 0.414
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Phosphate ion (94 Da, Ligand)
- Solute carrier family 22 member 6 (Complex from Rattus norvegicus)
- Synthetic nanobody (sybody) (Complex from Synthetic construct)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- Oat1 (Complex)
Cryo-EM structure of rat SLC22A6 bound to tenofovir
Resolution: 3.61 Å
EM Method: Single-particle
Fitted PDBs: 8bvs
Q-score: 0.402
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- [2-(6-amino-9h-purin-9-yl)-1-methylethoxy]methylphosphonic acid (287 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
Cryo-EM structure of rat SLC22A6 bound to probenecid
Resolution: 3.94 Å
EM Method: Single-particle
Fitted PDBs: 8bvt
Q-score: 0.364
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 4-(dipropylsulfamoyl)benzoic acid (285 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 8bw7
Q-score: 0.389
Parker JL, Kato T, Kuteyi G, Sitsel O, Newstead S
Nat Struct Mol Biol (2023) 30 pp. 1786-1793 [ DOI: doi:10.1038/s41594-023-01039-y Pubmed: 37482561 ]
- Chloride ion (35 Da, Ligand)
- Oat1 (Complex from Rattus norvegicus)
- Solute carrier family 22 member 6 (60 kDa, Protein from Rattus norvegicus)
- Synthetic nanobody (sybody) (16 kDa, Protein from synthetic construct)
- 2-oxoglutaric acid (146 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8749
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7b05
Q-score: 0.476
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Trpc4 in complex with inhibitor gfb-8749 (108 kDa, Complex from Danio rerio)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- 4-[4-[[4,4-bis(fluoranyl)cyclohexyl]methyl]-3-oxidanylidene-piperazin-1-yl]-5-chloranyl-1~{h}-pyridazin-6-one (360 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 7b0j
Q-score: 0.581
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Trpc4 membrane protein (108 kDa, Cellular component from Danio rerio)
- Calcium ion (40 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
TRPC4 in complex with inhibitor GFB-8438
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b0s
Q-score: 0.501
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- 5-chloranyl-4-[3-oxidanylidene-4-[[2-(trifluoromethyl)phenyl]methyl]piperazin-1-yl]-1~{h}-pyridazin-6-one (386 Da, Ligand)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Trpc4 in complex with inhibitor gfb-8438 (108 kDa, Cellular component from Danio rerio)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with inhibitor GFB-9289
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7b16
Q-score: 0.563
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- 5-chloranyl-4-(4-cyclohexyl-3-oxidanylidene-piperazin-1-yl)-1~{h}-pyridazin-6-one (310 Da, Ligand)
- Trpc4 in complex with inhibitor gfb-9289 (108 kDa, Cellular component from Danio rerio)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Calcium ion (40 Da, Ligand)
TRPC4 in complex with Calmodulin
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7b1g
Q-score: 0.489
Vinayagam D, Quentin D, Yu-Strzelczyk J, Sitsel O, Merino F, Stabrin M, Hofnagel O, Yu M, Ledeboer MW, Nagel G, Malojcic G, Raunser S
eLife (2020) 9 [ DOI: doi:10.7554/eLife.60603 Pubmed: 33236980 ]
- Calmodulin-1 (16 kDa, Protein from Mus musculus)
- (2r)-3-(phosphonooxy)propane-1,2-diyl dihexanoate (368 Da, Ligand)
- Transient receptor potential cation channel subfamily c member 4a (105 kDa, Protein from Danio rerio)
- Transient receptor potential cation channel subfamily c member 4a (Cellular component from Danio rerio)
- Trpc4 membrane protein in complex with calmodulin (126 kDa, Cellular component)
- Calmodulin-1 (Cellular component from Mus musculus)
- Calcium ion (40 Da, Ligand)
Structure of the Lifeact-F-actin complex
Resolution: 3.5 Å
EM Method: Helical reconstruction
Fitted PDBs: 7ad9
Q-score: 0.466
Belyy A, Merino F, Sitsel O, Raunser S
PLoS Biol (2020) 18 pp. e3000925-e3000925 [ DOI: doi:10.1371/journal.pbio.3000925 Pubmed: 33216759 ]
- Phosphate ion (94 Da, Ligand)
- Magnesium ion (24 Da, Ligand)
- Actin (Complex from Oryctolagus cuniculus)
- Adenosine-5'-diphosphate (427 Da, Ligand)
- Complex between skeletal actin from rabbit, phalloidin and lifeact (163 MDa, Complex)
- Actin, alpha skeletal muscle (42 kDa, Protein from Rabbit)
- Phalloidin (808 Da, Protein from synthetic construct)
- Lifeact (1 kDa, Protein from Saccharomyces cerevisiae)
- Phalloidin (Complex from synthetic construct)
- Lifeact (Complex from Saccharomyces cerevisiae)