Cryo-EM structure of the human TRPC1/C4 heteromer
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2025) 32 pp. 326-338 [ Pubmed: 39478185 DOI: doi:10.1038/s41594-024-01408-1 ]
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
Cryo-EM structure of the human TRPC1/C4 heteromer in complex with Pico145
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2025) 32 pp. 326-338 [ Pubmed: 39478185 DOI: doi:10.1038/s41594-024-01408-1 ]
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Structure of a trp channel complex, apo state (Complex from Homo sapiens)
- 7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)-8-[3-(trifluoromethyloxy)phenoxy]purine-2,6-dione (524 Da, Ligand)
- Short transient receptor potential channel 1 (91 kDa, Protein from Homo sapiens)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPC4 in lipid nanodiscs
Won J, Kim J, Kim J, Ko J, Park CH, Jeong B, Lee SE, Jeong H, Kim SH, Park H, So I, Lee HH
Nat Struct Mol Biol (2025) 32 pp. 326-338 [ Pubmed: 39478185 DOI: doi:10.1038/s41594-024-01408-1 ]
- Calcium ion (40 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Short transient receptor potential channel 4 (105 kDa, Protein from Homo sapiens)
- 2-(hexadecanoyloxy)-1-[(phosphonooxy)methyl]ethyl hexadecanoate (648 Da, Ligand)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Structure of a trp channel (Complex from Homo sapiens)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class1
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 7x6c
Q-score: 0.518
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in lipid nanodiscs, class2
Resolution: 3.59 Å
EM Method: Single-particle
Fitted PDBs: 8gvw
Q-score: 0.44
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- (2s)-3-(hexadecanoyloxy)-2-[(9z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate (760 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Calcium ion (40 Da, Ligand)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class2
Resolution: 3.91 Å
EM Method: Single-particle
Fitted PDBs: 8gvx
Q-score: 0.323
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Transient receptor potential (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the human TRPC5 ion channel in complex with G alpha i3 subunits, class1
Resolution: 3.93 Å
EM Method: Single-particle
Fitted PDBs: 7x6i
Q-score: 0.392
Won J, Kim J, Jeong H, Kim J, Feng S, Jeong B, Kwak M, Ko J, Im W, So I, Lee HH
Nat Commun (2023) 14 pp. 2550-2550 [ Pubmed: 37137991 DOI: doi:10.1038/s41467-023-38281-3 ]
- (2s)-2-(hexadecanoyloxy)-3-hydroxypropyl (9z)-octadec-9-enoate (594 Da, Ligand)
- Trp channel-g protein complex (Complex from Homo sapiens)
- Short transient receptor potential channel 5 (89 kDa, Protein from Homo sapiens)
- Cholesterol hemisuccinate (486 Da, Ligand)
- Trp channel (Complex from Homo sapiens)
- Phosphatidylethanolamine (734 Da, Ligand)
- Zinc ion (65 Da, Ligand)
- Guanosine-5'-triphosphate (523 Da, Ligand)
- G protein (Complex)
- Calcium ion (40 Da, Ligand)
- Guanine nucleotide-binding protein g(i) subunit alpha-3 (41 kDa, Protein from Homo sapiens)