10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6dfg
Q-score: 0.348
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg505 md39 sosip trimer in complex with mature bg18 fragment antigen binding (570 kDa, Complex)
- Bg18 fragment (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Mature bg18 fragment antigen binding heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mature bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6dfh
Q-score: 0.392
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Bg18 fragment antigen (Complex from Homo sapiens)
- Bg505 md64 n332-gt2 sosip trimer in complex with germline-reverted bg18 fragment antigen binding (570 kDa, Complex)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg18-like precursor hmp1 fragment antigen binding light chain (Protein from Homo sapiens)
- Hmp1 fragment antigen binding (Complex from Homo sapiens)
- Bg18-like precursor hmp1 fragment antigen binding heavy chain (Protein from Homo sapiens)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp1 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Hmp42 fragment antigen binding (Complex from Homo sapiens)
- Bg18-like precursor hmp42 fragment antigen binding heavy chain (Protein from Homo sapiens)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
- Bg18-like precursor hmp42 fragment antigen binding light chain (Protein from Homo sapiens)
- Bg505 md64 n332-gt5 sosip trimer (Complex from Human immunodeficiency virus 1)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp42 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
AMC011 HIV-1 Env SOSIP trimer in complex with autologous anti-HIV antibody ACS202
van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW
Nat Microbiol (2016) 2 pp. 16199-16199 [ Pubmed: 27841852 DOI: doi:10.1038/nmicrobiol.2016.199 ]
van Gils MJ, van den Kerkhof TL, Ozorowski G, Cottrell CA, Sok D, Pauthner M, Pallesen J, de Val N, Yasmeen A, de Taeye SW, Schorcht A, Gumbs S, Johanna I, Saye-Francisco K, Liang CH, Landais E, Nie X, Pritchard LK, Crispin M, Kelsoe G, Wilson IA, Schuitemaker H, Klasse PJ, Moore JP, Burton DR, Ward AB, Sanders RW
Nat Microbiol (2016) 2 pp. 16199-16199 [ Pubmed: 27841852 DOI: doi:10.1038/nmicrobiol.2016.199 ]
- Amc011v.4.2_sosip (Protein from Human immunodeficiency virus 1)
- Pgv04 fab hc (Protein from Homo sapiens)
- Pgv04 fab lc (Protein from Homo sapiens)
- Hiv clade b env sosip ectodomain trimer from the amsterdam cohort study patient amc011 in complex with fab from igg pgv04 (600 kDa, Complex)
CSF trimer in closed conformation
Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J
Nat Commun (2016) 7 pp. 12040-12040 [ DOI: doi:10.1038/ncomms12040 Pubmed: 27349805 ]
- Csf trimer in closed conformation (420 kDa, Sample)
- Csf (420 kDa, Protein from Human immunodeficiency virus)
CSF trimer in a post-fusion or intermediate state
Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J
Nat Commun (2016) 7 pp. 12040-12040 [ DOI: doi:10.1038/ncomms12040 Pubmed: 27349805 ]
- Csf (420 kDa, Protein from Human immunodeficiency virus)
- Csf trimer in a post-fusion or intermediate state (420 kDa, Sample)
CSF_closed_trimer in complex with the bnAb PGV04
Kong L, He L, de Val N, Vora N, Morris CD, Azadnia P, Sok D, Zhou B, Burton DR, Ward AB, Wilson IA, Zhu J
Nat Commun (2016) 7 pp. 12040-12040 [ DOI: doi:10.1038/ncomms12040 Pubmed: 27349805 ]
- Csf (570 kDa, Protein from Human immunodeficiency virus)
- Csf trimer closed, bound to pgv04 (570 kDa, Sample)
- Pgv04 (Protein from Homo sapiens)