10E8-GT10.2 immunogen in complex with human Fab 10E8 and mouse Fab W6-10
Resolution: 4.0 Å
EM Method: Single-particle
Fitted PDBs: 8sx3
Q-score: 0.378
Schiffner T, Phung I, Ray R, Irimia A, Tian M, Swanson O, Lee JH, Lee CD, Marina-Zarate E, Cho SY, Huang J, Ozorowski G, Skog PD, Serra AM, Rantalainen K, Allen JD, Baboo S, Rodriguez OL, Himansu S, Zhou J, Hurtado J, Flynn CT, McKenney K, Havenar-Daughton C, Saha S, Shields K, Schulze S, Smith ML, Liang CH, Toy L, Pecetta S, Lin YC, Willis JR, Sesterhenn F, Kulp DW, Hu X, Cottrell CA, Zhou X, Ruiz J, Wang X, Nair U, Kirsch KH, Cheng HL, Davis J, Kalyuzhniy O, Liguori A, Diedrich JK, Ngo JT, Lewis V, Phelps N, Tingle RD, Spencer S, Georgeson E, Adachi Y, Kubitz M, Eskandarzadeh S, Elsliger MA, Amara RR, Landais E, Briney B, Burton DR, Carnathan DG, Silvestri G, Watson CT, Yates 3rd JR, Paulson JC, Crispin M, Grigoryan G, Ward AB, Sok D, Alt FW, Wilson IA, Batista FD, Crotty S, Schief WR
Nat Immunol (2024) 25 pp. 1073-1082 [ DOI: doi:10.1038/s41590-024-01833-w Pubmed: 38816615 ]
- 10e8 light chain (22 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen in complex with human fab 10e8 and mouse fab w6-10 (Complex)
- 10e8 fab heavy chain (25 kDa, Protein from Homo sapiens)
- 10e8-gt10.2 immunogen (21 kDa, Protein from synthetic construct)
- W6-10 mouse fab heavy chain, w6-10 mouse light chain (Complex from Mus musculus)
- 10e8 fab heavy chain, 10e8 light chain (Complex from Homo sapiens)
- W6-10 mouse light chain (23 kDa, Protein from Mus musculus)
- W6-10 mouse fab heavy chain (23 kDa, Protein from Mus musculus)
- 10e8-gt10.2 immunogen (Complex from synthetic construct)
SARS-CoV-2-6P-Mut7 S protein (C3 symmetry)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ru1
Q-score: 0.563
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
SARS-CoV-2-6P-Mut7 S protein (asymmetric)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ru2
Q-score: 0.521
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru3
Q-score: 0.413
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru4
Q-score: 0.457
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ru5
Q-score: 0.315
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab in complex with sars-cov-2-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- Cc6.30 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ru8
Q-score: 0.334
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- Cc6.30 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab (Complex from Homo sapiens)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab in complex with sars-2-cov-6p-mut7 s protein (Complex)
BG505 MD39 SOSIP trimer in complex with mature BG18 fragment antigen binding
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6dfg
Q-score: 0.348
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg505 md39 sosip trimer in complex with mature bg18 fragment antigen binding (570 kDa, Complex)
- Bg18 fragment (Complex from Homo sapiens)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Mature bg18 fragment antigen binding heavy chain (25 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Mature bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
BG505 MD64 N332-GT2 SOSIP trimer in complex with germline-reverted BG18 fragment antigen binding
Resolution: 3.85 Å
EM Method: Single-particle
Fitted PDBs: 6dfh
Q-score: 0.392
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding light chain (22 kDa, Protein from Homo sapiens)
- Bg18 fragment antigen (Complex from Homo sapiens)
- Bg505 md64 n332-gt2 sosip trimer in complex with germline-reverted bg18 fragment antigen binding (570 kDa, Complex)
- Envelope glycoprotein gp160 (18 kDa, Protein from Human immunodeficiency virus 1)
- Germline-reverted bg18 fragment antigen binding heavy chain (24 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Sosip trimer (Complex from Human immunodeficiency virus 1)
Steichen JM, Lin YC, Havenar-Daughton C, Pecetta S, Ozorowski G, Willis JR, Toy L, Sok D, Liguori A, Kratochvil S, Torres JL, Kalyuzhniy O, Melzi E, Kulp DW, Raemisch S, Hu X, Bernard SM, Georgeson E, Phelps N, Adachi Y, Kubitz M, Landais E, Umotoy J, Robinson A, Briney B, Wilson IA, Burton DR, Ward AB, Crotty S, Batista FD, Schief WR
Science (2019) 366 [ Pubmed: 31672916 DOI: doi:10.1126/science.aax4380 ]
- Bg18-like precursor hmp1 fragment antigen binding light chain (Protein from Homo sapiens)
- Hmp1 fragment antigen binding (Complex from Homo sapiens)
- Bg18-like precursor hmp1 fragment antigen binding heavy chain (Protein from Homo sapiens)
- Rm20a3 fragment antigen binding heavy chain (Protein from Macaca mulatta)
- Rm20a3 fragment antigen binding (Complex from Macaca mulatta)
- Bg505 md64 n332-gt5 sosip (Protein from Human immunodeficiency virus 1)
- Rm20a3 fragment antigen binding light chain (Protein from Macaca mulatta)
- Bg505 md64 n332-gt5 sosip trimer in complex with bg18-like precursor hmp1 fragment antigen binding and base-binding rm20a3 fragment antigen binding (720 kDa, Complex)
- Sosip trimer (Complex from Human immunodeficiency virus 1)