HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tq1
Q-score: 0.512
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Sewall LM, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D
PLoS Pathog (2024) 20 pp. e1012042-e1012042 [ DOI: doi:10.1371/journal.ppat.1012042 Pubmed: 39250525 ]
- Nhp rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Nhp rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with bovine bess4 fab and nhp rm20a3 fab (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bovine bess4 fab heavy chain (17 kDa, Protein from Bos taurus)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 7t2p
Q-score: 0.422
Zhao F, Berndsen ZT, Pedreno-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D
Nat Commun (2022) 13 pp. 5236-5236 [ DOI: doi:10.1038/s41467-022-32783-2 Pubmed: 36068229 ]
- K11 fab light chain (25 kDa, Protein from Macaca mulatta)
- K11 fab heavy chain (53 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (18 kDa, Protein from Simian immunodeficiency virus)
- Envelope glycoprotein gp120 (60 kDa, Protein from Simian immunodeficiency virus)
- Sivmac239.k180s sosip trimer in complex with 3 copies of k11 fab (Complex from Simian immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 7t4g
Q-score: 0.406
Zhao F, Berndsen ZT, Pedreno-Lopez N, Burns A, Allen JD, Barman S, Lee WH, Chakraborty S, Gnanakaran S, Sewall LM, Ozorowski G, Limbo O, Song G, Yong P, Callaghan S, Coppola J, Weisgrau KL, Lifson JD, Nedellec R, Voigt TB, Laurino F, Louw J, Rosen BC, Ricciardi M, Crispin M, Desrosiers RC, Rakasz EG, Watkins DI, Andrabi R, Ward AB, Burton DR, Sok D
Nat Commun (2022) 13 pp. 5236-5236 [ DOI: doi:10.1038/s41467-022-32783-2 Pubmed: 36068229 ]
- Sivmac239.k180s sosip trimer in complex with 3 copies of k11 igg (Complex from Simian immunodeficiency virus)
- K11 igg light chain (25 kDa, Protein from Macaca mulatta)
- Envelope glycoprotein gp41 (18 kDa, Protein from Simian immunodeficiency virus)
- Envelope glycoprotein gp120 (60 kDa, Protein from Simian immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- K11 igg heavy chain (53 kDa, Protein from Macaca mulatta)
BG505 SOSIP.v5.2 in complex with the polyclonal Fab pAbC-1 from animal Rh.4O9
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7mdt
Q-score: 0.481
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ DOI: doi:10.1126/sciadv.abk2039 Pubmed: 35044813 ]
- Rh4o9.8 monoclonal antibody heavy chain (12 kDa, Protein from Macaca mulatta)
- Rh4o9.8 monoclonal antibody light chain (11 kDa, Protein from Macaca mulatta)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.v5.2 in complex with the polyclonal fab sample isolated from animal rh4o9. (Complex from Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 SOSIP MD39 in complex with the monoclonal antibodies Rh.33104 mAb.1 and RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7mdu
Q-score: 0.517
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ DOI: doi:10.1126/sciadv.abk2039 Pubmed: 35044813 ]
- Rh.33104 mab.1 heavy chain (12 kDa, Protein from Macaca mulatta)
- Surface protein gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Rm20a3 mab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505 sosip md39 in complex with the monoclonal antibodies rh.33104 mab.1 and rm20a3 (Complex from Macaca mulatta)
- Rm20a3 mab light chain (11 kDa, Protein from Macaca mulatta)
- Rh.33104 mab.1 light chain (11 kDa, Protein from Macaca mulatta)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
BG505 SOSIP.v5.2(7S) in complex with the monoclonal antibodies Rh.33172 mAb.1 and RM19R
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7mep
Q-score: 0.486
Antanasijevic A, Bowman CA, Kirchdoerfer RN, Cottrell CA, Ozorowski G, Upadhyay AA, Cirelli KM, Carnathan DG, Enemuo CA, Sewall LM, Nogal B, Zhao F, Groschel B, Schief WR, Sok D, Silvestri G, Crotty S, Bosinger SE, Ward AB
Sci Adv (2022) 8 pp. eabk2039-eabk2039 [ DOI: doi:10.1126/sciadv.abk2039 Pubmed: 35044813 ]
- Rh.33172 mab.1 heavy chain (14 kDa, Protein from Macaca mulatta)
- Rm19r mab light chain (11 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) in complex with the monoclonal antibodies rh.33172 mab.1 and rm19r (Complex)
- Bg505 sosipv5.2(7s) - gp120 (74 kDa, Protein from Human immunodeficiency virus)
- Monoclonal antibodies rh.33172 mab.1 and rm19r (Complex from Macaca mulatta)
- Rm19r mab heavy chain (13 kDa, Protein from Macaca mulatta)
- Bg505 sosip.v5.2(7s) (Complex from Human immunodeficiency virus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rh.33172 mab.1 light chain (11 kDa, Protein from Macaca mulatta)
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 6vo1
Q-score: 0.389
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ Pubmed: 32866207 DOI: doi:10.1371/journal.ppat.1008753 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2 (Complex from Human immunodeficiency virus 1)
- Fab rm20j (Complex from Macaca mulatta)
- Bg505 sosip.v5.2 in complex with rhesus macaque fab rm20j (Complex)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Rm20j kappa light chain (11 kDa, Protein from Macaca mulatta)
- Rm20j heavy chain fab (12 kDa, Protein from Macaca mulatta)
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6vlr
Q-score: 0.337
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ Pubmed: 32866207 DOI: doi:10.1371/journal.ppat.1008753 ]
- Rm20e1 fab kappa chain (12 kDa, Protein from Macaca mulatta)
- Rm20e1 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Pgt122 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg505 sosipv5.2 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2 in complex with rhesus macaque fab rm20e1 (Complex from Human immunodeficiency virus 1)
BG505 SOSIP.v4.1 in complex with rhesus macaque Fab RM20F
Resolution: 4.25 Å
EM Method: Single-particle
Fitted PDBs: 6vn0
Q-score: 0.345
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ Pubmed: 32866207 DOI: doi:10.1371/journal.ppat.1008753 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Envelope glycoprotein gp160 (53 kDa, Protein from Human immunodeficiency virus 1)
- Bg505 sosip.v4.1 in complex with rhesus macaque fab rm20f (Complex from Human immunodeficiency virus 1)
- Rm20f fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Rm20f kappa chain (11 kDa, Protein from Macaca mulatta)