HIV-1 BG505 Env SOSIP in complex with bovine Fab Bess4 and non-human primate Fab RM20A3
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8tq1
Q-score: 0.512
Altman PX, Ozorowski G, Stanfield RL, Haakenson J, Appel M, Parren M, Lee WH, Sang H, Woehl J, Saye-Francisco K, Sewall LM, Joyce C, Song G, Porter K, Landais E, Andrabi R, Wilson IA, Ward AB, Mwangi W, Smider VV, Burton DR, Sok D
PLoS Pathog (2024) 20 pp. e1012042-e1012042 [ DOI: doi:10.1371/journal.ppat.1012042 Pubmed: 39250525 ]
- Nhp rm20a3 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Nhp rm20a3 fab light chain (13 kDa, Protein from Macaca mulatta)
- Hiv-1 bg505 sosip env in complex with bovine bess4 fab and nhp rm20a3 fab (Complex from Human immunodeficiency virus 1)
- Transmembrane protein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- Bovine bess4 fab heavy chain (17 kDa, Protein from Bos taurus)
- Hiv-1 envelope glycoprotein bg505 sosip.664 gp120 (57 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.34 Å
EM Method: Single-particle
Fitted PDBs: 8dt8
Q-score: 0.443
Misson Mindrebo L, Liu H, Ozorowski G, Tran Q, Woehl J, Khalek I, Smith JM, Barman S, Zhao F, Keating C, Limbo O, Verma M, Liu J, Stanfield RL, Zhu X, Turner HL, Sok D, Huang PS, Burton DR, Ward AB, Wilson IA, Jardine JG
PNAS (2023) 120 pp. e2216612120-e2216612120 [ DOI: doi:10.1073/pnas.2216612120 Pubmed: 37276407 ]
- Lm18 nanobody (14 kDa, Protein from synthetic construct)
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Lm18/nb136 bispecific tetra-nanobody immunoglobulin in complex with sars-cov-2-6p-mut7 s protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Nb136 nanobody (13 kDa, Protein from synthetic construct)
SARS-CoV-2-6P-Mut7 S protein (C3 symmetry)
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 7ru1
Q-score: 0.563
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
SARS-CoV-2-6P-Mut7 S protein (asymmetric)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7ru2
Q-score: 0.521
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (non-uniform refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru3
Q-score: 0.413
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
CC6.33 IgG in complex with SARS-CoV-2-6P-Mut7 S protein (RBD/Fv local refinement)
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7ru4
Q-score: 0.457
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg (Complex from Homo sapiens)
- Cc6.33 igg kappa chain fv (11 kDa, Protein from Homo sapiens)
- Cc6.33 igg in complex with sars-2-cov-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.33 igg heavy chain fv (12 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.6 Å
EM Method: Single-particle
Fitted PDBs: 7ru5
Q-score: 0.315
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab in complex with sars-cov-2-6p-mut7 s protein (Complex)
- Spike glycoprotein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- Cc6.30 fab (Complex from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7ru8
Q-score: 0.334
Zhao F, Keating C, Ozorowski G, Shaabani N, Francino-Urdaniz IM, Barman S, Limbo O, Burns A, Zhou P, Ricciardi MJ, Woehl J, Tran Q, Turner HL, Peng L, Huang D, Nemazee D, Andrabi R, Sok D, Teijaro JR, Whitehead TA, Ward AB, Burton DR, Jardine JG
iScience (2022) 25 pp. 104914-104914 [ DOI: doi:10.1016/j.isci.2022.104914 Pubmed: 35971553 ]
- Spike glycoprotein (141 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab heavy chain fv (13 kDa, Protein from Homo sapiens)
- Cc6.30 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Cc6.30 fab (Complex from Homo sapiens)
- Cc6.30 fab kappa chain fv (11 kDa, Protein from Homo sapiens)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Cc6.30 fab in complex with sars-2-cov-6p-mut7 s protein (Complex)
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20J
Resolution: 3.88 Å
EM Method: Single-particle
Fitted PDBs: 6vo1
Q-score: 0.389
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ Pubmed: 32866207 DOI: doi:10.1371/journal.ppat.1008753 ]
- Envelope glycoprotein gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2 (Complex from Human immunodeficiency virus 1)
- Fab rm20j (Complex from Macaca mulatta)
- Bg505 sosip.v5.2 in complex with rhesus macaque fab rm20j (Complex)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Rm20j kappa light chain (11 kDa, Protein from Macaca mulatta)
- Rm20j heavy chain fab (12 kDa, Protein from Macaca mulatta)
BG505 SOSIP.v5.2 in complex with rhesus macaque Fab RM20E1 and PGT122 Fab
Resolution: 4.42 Å
EM Method: Single-particle
Fitted PDBs: 6vlr
Q-score: 0.337
Cottrell CA, van Schooten J, Bowman CA, Yuan M, Oyen D, Shin M, Morpurgo R, van der Woude P, van Breemen M, Torres JL, Patel R, Gross J, Sewall LM, Copps J, Ozorowski G, Nogal B, Sok D, Rakasz EG, Labranche C, Vigdorovich V, Christley S, Carnathan DG, Sather DN, Montefiori D, Silvestri G, Burton DR, Moore JP, Wilson IA, Sanders RW, Ward AB, van Gils MJ
PLoS Pathog (2020) 16 pp. e1008753-e1008753 [ Pubmed: 32866207 DOI: doi:10.1371/journal.ppat.1008753 ]
- Rm20e1 fab kappa chain (12 kDa, Protein from Macaca mulatta)
- Rm20e1 fab heavy chain (13 kDa, Protein from Macaca mulatta)
- Pgt122 fab heavy chain (14 kDa, Protein from Homo sapiens)
- Envelope glycoprotein gp120 (53 kDa, Protein from Human immunodeficiency virus 1)
- Pgt122 fab light chain (11 kDa, Protein from Homo sapiens)
- Bg505 sosipv5.2 gp41 (17 kDa, Protein from Human immunodeficiency virus 1)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Bg505 sosip.v5.2 in complex with rhesus macaque fab rm20e1 (Complex from Human immunodeficiency virus 1)