SARS-CoV-2 spike in complex with AHB2-2GS-SB175
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7uhc
Q-score: 0.465
Hunt AC, Case JB, Park YJ, Cao L, Wu K, Walls AC, Liu Z, Bowen JE, Yeh HW, Saini S, Helms L, Zhao YT, Hsiang TY, Starr TN, Goreshnik I, Kozodoy L, Carter L, Ravichandran R, Green LB, Matochko WL, Thomson CA, Vogeli B, Kruger A, VanBlargan LA, Chen RE, Ying B, Bailey AL, Kafai NM, Boyken SE, Ljubetic A, Edman N, Ueda G, Chow CM, Johnson M, Addetia A, Navarro MJ, Panpradist N, Gale Jr M, Freedman BS, Bloom JD, Ruohola-Baker H, Whelan SPJ, Stewart L, Diamond MS, Veesler D, Jewett MC, Baker D
Sci Transl Med (2022) 14 pp. eabn1252-eabn1252 [ DOI: doi:10.1126/scitranslmed.abn1252 Pubmed: 35412328 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (17 kDa, Protein from synthetic construct)
- Sars-cov-2 spike in complex with multivalent minibinder ahb2-2gs-sb175 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 hexapro spike protein (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Multivalent miniprotein inhibitor ahb2-2gs-sb175 (Complex from Synthetic construct)
SARS-CoV-2 spike in complex with LCB1 (2RBDs open)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7jzl
Q-score: 0.493
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lcb1 (6 kDa, Protein from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)
- Lcb1 (Complex from synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 spike in complex with LCB3 (2RBDs open)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7jzn
Q-score: 0.478
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lcb3 (11 kDa, Protein from synthetic construct)
- Lcb3 (Complex from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
Cryo-EM structure of a de novo designed 16-helix transmembrane nanopore, TMHC8_R.
Resolution: 7.6 Å
EM Method: Single-particle
Fitted PDBs: 6u1s
Q-score: 0.11
Xu C, Lu P, Gamal El-Din TM, Pei X, Johnson MJ, Uyeda A, Bick MJ, Jiang D, Hsia Y, Brunette TJ, Ma D, Lynch E, Boyken SE, Huang P, Stewart L, Kollman JK, Luisi BF, Matsuura T, Catterall WA, Baker D
To Be Published
Resolution: 5.9 Å
EM Method: Helical reconstruction
Fitted PDBs: 6e9r
Q-score: 0.157
Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D
Science (2018) 362 pp. 705-709 [ DOI: doi:10.1126/science.aau3775 Pubmed: 30409885 ]
- Dhf46 filament (18 kDa, Protein from synthetic construct)
- Dhf46 filament (Complex from synthetic construct)
Resolution: 7.8 Å
EM Method: Helical reconstruction
Fitted PDBs: 6e9x
Q-score: 0.156
Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D
Science (2018) 362 pp. 705-709 [ DOI: doi:10.1126/science.aau3775 Pubmed: 30409885 ]
- Dhf91 filament (Complex from synthetic construct)
- Dhf91 filament (17 kDa, Protein from synthetic construct)
Resolution: 4.3 Å
EM Method: Helical reconstruction
Fitted PDBs: 6e9y
Q-score: 0.298
Shen H, Fallas JA, Lynch E, Sheffler W, Parry B, Jannetty N, Decarreau J, Wagenbach M, Vicente JJ, Chen J, Wang L, Dowling Q, Oberdorfer G, Stewart L, Wordeman L, De Yoreo J, Jacobs-Wagner C, Kollman J, Baker D
Science (2018) 362 pp. 705-709 [ DOI: doi:10.1126/science.aau3775 Pubmed: 30409885 ]
- Dhf38 filament (Complex from synthetic construct)
- Dhf38 filament (25 kDa, Protein from synthetic construct)