SARS-CoV-2 spike in complex with LCB1 (2RBDs open)
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 7jzl
Q-score: 0.493
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lcb1 (Complex from synthetic construct)
- Lcb1 (6 kDa, Protein from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 spike in complex with LCB3 (local refinement of the RBD and LCB3)
Resolution: 3.5 Å
EM Method: Single-particle
Fitted PDBs: 7jzm
Q-score: 0.451
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Lcb3 (Complex from synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lcb3 (11 kDa, Protein from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)
SARS-CoV-2 spike in complex with LCB3 (2RBDs open)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7jzn
Q-score: 0.478
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Lcb3 (Complex from synthetic construct)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lcb3 (11 kDa, Protein from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
SARS-CoV-2 spike in complex with LCB1 (local refinement of the RBD and LCB1)
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7jzu
Q-score: 0.481
Cao L, Goreshnik I, Coventry B, Case JB, Miller L, Kozodoy L, Chen RE, Carter L, Walls AC, Park YJ, Strauch EM, Stewart L, Diamond MS, Veesler D, Baker D
Science (2020) 370 pp. 426-431 [ Pubmed: 32907861 DOI: doi:10.1126/science.abd9909 ]
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike (Complex from Severe acute respiratory syndrome coronavirus 2)
- Lcb1 (Complex from synthetic construct)
- Lcb1 (7 kDa, Protein from synthetic construct)
- De novo design of picomolar sars-cov-2 miniprotein inhibitors (Complex)