Monomeric Lassa glycoprotein bound to 25.10C Fab and two interior-binding rabbit polyclonal Fabs
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8vcv
Q-score: 0.579
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- Lineage iv lassa virus glycoprotein (josiah) in complex with rabbit polyclonal antibody (gpc-c epitope) (Complex from Oryctolagus cuniculus)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rabbit polyclonal fv light chain (9 kDa, Protein from Oryctolagus cuniculus)
- Rabbit polyclonal fv heavy chain (10 kDa, Protein from Oryctolagus cuniculus)
- Glycoprotein g2 (44 kDa, Protein from Lassa virus Josiah)
Lineage IV Lassa virus glycoprotein (Josiah) in complex with monoclonal antibody 8.9F
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 9cj7
Q-score: 0.512
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- Fv region of 8.9f heavy chain (31 kDa, Protein from Homo sapiens)
- Glycoprotein g1 (29 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lineage iv lassa virus glycoprotein (josiah) in complex with monoclonal antibody 8.9f (Complex from Oryctolagus cuniculus)
- Fv region of 8.9f light chain (25 kDa, Protein from Homo sapiens)
- Glycoprotein g2 (46 kDa, Protein from Lassa virus Josiah)
Resolution: 3.74 Å
EM Method: Single-particle
Fitted PDBs: 9cj8
Q-score: 0.423
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- Glycoprotein g1 (29 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rabbit polyclonal fv light chain (8 kDa, Protein from Oryctolagus cuniculus)
- Lineage iv lassa virus glycoprotein (josiah) in complex with rabbit polyclonal antibody (ll-1 epitope) (Complex from Oryctolagus cuniculus)
- Glycoprotein g2 (44 kDa, Protein from Lassa virus Josiah)
- Rabbit polyclonal fv heavy chain (9 kDa, Protein from Oryctolagus cuniculus)
Resolution: 3.45 Å
EM Method: Single-particle
Fitted PDBs: 9ck7
Q-score: 0.454
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- Glycoprotein gp1 (29 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Rabbit polyclonal fv heavy chain (10 kDa, Protein from Oryctolagus cuniculus)
- Lineage iv lassa virus glycoprotein (josiah) in complex with rabbit polyclonal antibody (gpc-a-1 epitope) (Complex from Oryctolagus cuniculus)
- Rabbit polyclonal fv light chain (9 kDa, Protein from Oryctolagus cuniculus)
- Glycoprotein g2 (46 kDa, Protein from Lassa virus Josiah)
Resolution: 3.04 Å
EM Method: Single-particle
Fitted PDBs: 9ck8
Q-score: 0.528
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- Glycoprotein gp1 (29 kDa, Protein from Lassa virus Josiah)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Lineage iv lassa virus glycoprotein (josiah) in complex with rabbit polyclonal antibody (gpc-a-2 epitope) (Complex from Oryctolagus cuniculus)
- Rabbit polyclonal fv light chain (9 kDa, Protein from Oryctolagus cuniculus)
- Rabbit polyclonal fv heavy chain (10 kDa, Protein from Oryctolagus cuniculus)
- Glycoprotein g2 (46 kDa, Protein from Lassa virus Josiah)
Lassa GPC (strain Josiah) bound to rabbit polyclonal fusion-peptide-targeting antibody FP-1
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8tye
Q-score: 0.421
Brouwer PJM, Perrett HR, Beaumont T, Nijhuis H, Kruijer S, Burger JA, Bontjer I, Lee WH, Ferguson JA, Schauflinger M, Muller-Krauter H, Sanders RW, Strecker T, van Gils MJ, Ward AB
Cell Rep (2024) 43 pp. 114708-114708 [ DOI: doi:10.1016/j.celrep.2024.114708 Pubmed: 39243373 ]
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein g1, glycoprotein g2, 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase fusion protein (Complex from Lassa virus Josiah)
- Polyclonal antibody fp-1 heavy chain, polyclonal antibody fp-1 light chain (Complex from Oryctolagus cuniculus)
- Polyclonal fv heavy chain (9 kDa, Protein from Oryctolagus cuniculus)
- Glycoprotein gp2 (44 kDa, Protein from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8))
- Heterotrimeric lassa gpc bound to heterodimeric rabbit polyclonal fusion-peptide-targeting antibody fp-1 (Complex)
- Glycoprotein gp1 (29 kDa, Protein from Lassa virus (strain Mouse/Sierra Leone/Josiah/1976))
- Polyclonal fv light chain (8 kDa, Protein from Oryctolagus cuniculus)
Structure of lineage IV Lassa virus glycoprotein complex (strain Josiah)
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 8ejd
Q-score: 0.373
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- Glycoprotein g2 (44 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein g1 (29 kDa, Protein from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Structure of lineage II Lassa virus glycoprotein complex (strain NIG08-A41)
Resolution: 3.69 Å
EM Method: Single-particle
Fitted PDBs: 8eje
Q-score: 0.391
Perrett HR, Brouwer PJM, Hurtado J, Newby ML, Liu L, Muller-Krauter H, Muller Aguirre S, Burger JA, Bouhuijs JH, Gibson G, Messmer T, Schieffelin JS, Antanasijevic A, Boons GJ, Strecker T, Crispin M, Sanders RW, Briney B, Ward AB
Cell Rep (2023) 42 pp. 112524-112524 [ Pubmed: 37209096 DOI: doi:10.1016/j.celrep.2023.112524 ]
- Lassa mammarenavirus gpc (275 kDa, Complex from Lassa mammarenavirus)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
- Glycoprotein gp2 (19 kDa, Protein from Lassa mammarenavirus)
- Glycoprotein gp1 (28 kDa, Protein from Lassa mammarenavirus)