Cryo-EM structure of the DMCHA-bound mTAAR9-Gs complex
Resolution: 3.46 Å
EM Method: Single-particle
Fitted PDBs: 8itf
Q-score: 0.491
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- ~{n},~{n}-dimethylcyclohexanamine (127 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the dmcha-bound mtaar9-gs complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PEA-bound mTAAR9-Golf complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iw1
Q-score: 0.436
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Cryo-em structure of the pea-bound mtaar9-golf complex (Complex from Mus musculus)
- Guanine nucleotide-binding protein g(i) subunit alpha-1,guanine nucleotide-binding protein g(olf) subunit alpha (29 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SPE-bound mTAAR9-Gs complex
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8iw4
Q-score: 0.508
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the spe-bound mtaar9-gs complex (Complex from Mus musculus)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Spermidine (145 Da, Ligand)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the PEA-bound mTAAR9-Gs complex
Resolution: 2.97 Å
EM Method: Single-particle
Fitted PDBs: 8iw7
Q-score: 0.518
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
- 2-phenylethylamine (122 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the pea-bound mtaar9-gs complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Guanine nucleotide-binding protein subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Escherichia coli BL21(DE3))
Cryo-EM structure of the CAD-bound mTAAR9-Gs complex
Resolution: 3.08 Å
EM Method: Single-particle
Fitted PDBs: 8iw9
Q-score: 0.546
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Cryo-em structure of the cad-bound mtaar9-gs complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (42 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (41 kDa, Protein from Homo sapiens)
Cryo-EM structure of the SPE-mTAAR9 complex
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8iwe
Q-score: 0.493
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- Cryo-em structure of the spe-bound mtaar9 complex (Complex from Mus musculus)
- Spermidine (145 Da, Ligand)
Cryo-EM structure of the PEA-bound mTAAR9 complex
Resolution: 3.17 Å
EM Method: Single-particle
Fitted PDBs: 8iwm
Q-score: 0.491
Guo L, Cheng J, Lian S, Liu Q, Lu Y, Zheng Y, Zhu K, Zhang M, Kong Y, Zhang C, Rong N, Zhuang Y, Fang G, Jiang J, Zhang T, Han X, Liu Z, Xia M, Liu S, Zhang L, Liberles SD, Yu X, Xu Y, Yang F, Li Q, Sun JP
Nature (2023) 618 pp. 193-200 [ DOI: doi:10.1038/s41586-023-06106-4 Pubmed: 37225986 ]
- Cryo-em structure of the pea-bound mtaar9 complex (Complex from Mus musculus)
- Trace amine-associated receptor 9 (38 kDa, Protein from Mus musculus)
- 2-phenylethylamine (122 Da, Ligand)
Structural basis for the tethered peptide activation of adhesion GPCRs
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7ept
Q-score: 0.509
Ping YQ, Xiao P, Yang F, Zhao RJ, Guo SC, Yan X, Wu X, Zhang C, Lu Y, Zhao F, Zhou F, Xi YT, Yin W, Liu FZ, He DF, Zhang DL, Zhu ZL, Jiang Y, Du L, Feng SQ, Schoneberg T, Liebscher I, Xu HE, Sun JP
Nature (2022) 604 pp. 763-770 [ Pubmed: 35418678 DOI: doi:10.1038/s41586-022-04619-y ]
- Gpr133-gs complex (Complex from Homo sapiens)
- Gpr133 (Protein from Homo sapiens)
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 7wui
Q-score: 0.418
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X
Nature (2022) 604 pp. 771-778 [ DOI: doi:10.1038/s41586-022-04590-8 Pubmed: 35418677 ]
- Nanobody-35 (Complex from Lama glama)
- Nanobody-35 (13 kDa, Protein from Lama glama)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Ip15 (1 kDa, Protein from synthetic construct)
- Ip15 (Complex)
- Cryo-em structure of the adgrg2-fl-ip15-gs complex (253 MDa, Complex)
- Adhesion g-protein coupled receptor g2,mcherry (126 kDa, Protein from Mus musculus)
- Scfv16 (Complex from synthetic construct)
- Gs (Complex from Homo sapiens)
- Adhesion g-protein coupled receptor g2 (Complex from Mus musculus)
Tethered peptide activation mechanism of adhesion GPCRs ADGRG2 and ADGRG4
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7wuj
Q-score: 0.474
Xiao P, Guo S, Wen X, He QT, Lin H, Huang SM, Gou L, Zhang C, Yang Z, Zhong YN, Yang CC, Li Y, Gong Z, Tao XN, Yang ZS, Lu Y, Li SL, He JY, Wang C, Zhang L, Kong L, Sun JP, Yu X
Nature (2022) 604 pp. 771-778 [ DOI: doi:10.1038/s41586-022-04590-8 Pubmed: 35418677 ]
- Nanobody-35 (Complex from Lama glama)
- Nanobody-35 (13 kDa, Protein from Lama glama)
- Mini-gs (41 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (26 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Adhesion g-protein coupled receptor g4,uncharacterized protein (71 kDa, Protein from Psychromonas sp. B3M02)
- Cryo-em structure of the adgr4-beta-gs complex (Complex)
- Scfv16 (Complex from synthetic construct)
- Gs (Complex from Homo sapiens)