Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.2
Resolution: 3.05 Å
EM Method: Single-particle
Fitted PDBs: 8zf4
Q-score: 0.497
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xGPR4-Gs complex in pH6.7
Resolution: 3.15 Å
EM Method: Single-particle
Fitted PDBs: 8zf7
Q-score: 0.495
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Cryo-EM structure of the receptor of xtGPR4-Gs complex in pH7.2
Resolution: 3.78 Å
EM Method: Single-particle
Fitted PDBs: 8zfb
Q-score: 0.433
Wen X, Shang P, Chen H, Guo L, Rong N, Jiang X, Li X, Liu J, Yang G, Zhang J, Zhu K, Meng Q, He X, Wang Z, Liu Z, Cheng H, Zheng Y, Zhang B, Pang J, Liu Z, Xiao P, Chen Y, Liu L, Luo F, Yu X, Yi F, Zhang P, Yang F, Deng C, Sun JP
Cell (2025) 188 pp. 653-670.e24 [ Pubmed: 39753131 DOI: doi:10.1016/j.cell.2024.12.001 ]
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.49 Å
EM Method: Single-particle
Fitted PDBs: 8x9s
Q-score: 0.506
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Rattus norvegicus)
- Complex of gpr133 with agonist and g protein trime (Complex from Bos taurus)
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Bos taurus)
- Gs protein alpha subunit (41 kDa, Protein from Bos taurus)
Identification, structure and agonist design of an androgen membrane receptor.
Resolution: 3.53 Å
EM Method: Single-particle
Fitted PDBs: 9iv2
Q-score: 0.503
Yang Z, Ping YQ, Wang MW, Zhang C, Zhou SH, Xi YT, Zhu KK, Ding W, Zhang QY, Song ZC, Zhao RJ, He ZL, Wang MX, Qi L, Ullmann C, Ricken A, Schoneberg T, Gan ZJ, Yu X, Xiao P, Yi F, Liebscher I, Sun JP
Cell (2025) [ Pubmed: 39884271 DOI: doi:10.1016/j.cell.2025.01.006 ]
- Adhesion g-protein coupled receptor d1 (65 kDa, Protein from Homo sapiens)
- Gs protein alpha subunit (41 kDa, Protein from Homo sapiens)
- 5-alpha-dihydrotestosterone (290 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Complex of gpr133 with agonist and g protein trime (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
Cryo-EM structure of the C16:0 ceramide-bound FPR2-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8y62
Q-score: 0.491
Sun JP, Jiang CT, Kong W, Yu X, Cai K, Guo LL
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- N-formyl peptide receptor 2 (38 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- Cryo-em structure of the c16:0 ceramide-bound fpr2-gi complex (Complex from Homo sapiens)
- N-((e,2s,3r)-1,3-dihydroxyoctadec-4-en-2-yl)palmitamide (537 Da, Ligand)
Cryo-EM structure of the C20:0 ceramide-bound FPR2-Gi complex
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8y63
Q-score: 0.454
Sun JP, Jiang CT, Kong W, Yu X, Cai K, Guo LL
To Be Published
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from synthetic construct)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cer(d18:0/20:0) (596 Da, Ligand)
- Cryo-em structure of the c20:0 ceramide-bound fpr2-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (6 kDa, Protein from Homo sapiens)
- N-formyl peptide receptor 2 (38 kDa, Protein from Homo sapiens)
Cryo-EM structure of urea bound human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xda
Q-score: 0.54
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
- Homotrimer complex of human urea transporter (Complex from Homo sapiens)
- Urea transporter 2 (43 kDa, Protein from Homo sapiens)
- Urea (60 Da, Ligand)
- Water (18 Da, Ligand)
Cryo-EM structure of human urea transporter A2.
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 8xdb
Q-score: 0.515
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]
Cryo-EM structure of human urea transporter A2.
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8xdc
Q-score: 0.562
Huang SM, Huang ZZ, Liu L, Xiong MY, Zhang C, Cai BY, Wang MW, Cai K, Jia YL, Wang JL, Zhang MH, Xie YH, Li M, Zhang H, Weng CH, Wen X, Li Z, Sun Y, Yi F, Yang Z, Xiao P, Yang F, Yu X, Tie L, Yang BX, Sun JP
Nat Commun (2024) 15 pp. 10226-10226 [ Pubmed: 39587082 DOI: doi:10.1038/s41467-024-54305-y ]