Cryo-EM structure of the amthamine-bound H2R-Gs complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yut
Q-score: 0.529
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Amthamine-bound h2r-gs complex (Complex from Homo sapiens)
- 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine (157 Da, Ligand)
- Histamine h2 receptor (46 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(s) subunit alpha isoforms short (43 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Nanobody-35 (13 kDa, Protein from synthetic construct)
Cryo-EM structure of the histamine-bound H3R-Gi complex
Resolution: 2.7 Å
EM Method: Single-particle
Fitted PDBs: 8yuu
Q-score: 0.566
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Histamine (111 Da, Ligand)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of the immepip-bound H3R-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8yuv
Q-score: 0.532
Shen Q, Tang X, Wen X, Cheng S, Xiao P, Zang SK, Shen DD, Jiang L, Zheng Y, Zhang H, Xu H, Mao C, Zhang M, Hu W, Sun JP, Zhang Y, Chen Z
Adv Sci (2024) 11 pp. e2310120-e2310120 [ DOI: doi:10.1002/advs.202310120 Pubmed: 38647423 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (39 kDa, Protein from Homo sapiens)
- 4-(1h-imidazol-5-ylmethyl)piperidine (165 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Histamine-bound h3r-gi complex (Complex from Homo sapiens)
- Histamine h3 receptor (50 kDa, Protein from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Scfv16 (28 kDa, Protein from Mus musculus)
Cryo-EM structure of the inactive CD97
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 8ikj
Q-score: 0.301
Cryo-EM structure of the CD97-G13 complex
Resolution: 2.33 Å
EM Method: Single-particle
Fitted PDBs: 8ikl
Q-score: 0.59
Mao C, Zhao RJ, Dong YJ, Gao M, Chen LN, Zhang C, Xiao P, Guo J, Qin J, Shen DD, Ji SY, Zang SK, Zhang H, Wang WW, Shen Q, Sun JP, Zhang Y
Mol Cell (2024) 84 pp. 570-583.e7 [ Pubmed: 38215752 DOI: doi:10.1016/j.molcel.2023.12.020 ]
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(13) subunit alpha isoforms short (26 kDa, Protein from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (Cellular component from Homo sapiens)
- Adhesion g protein-coupled receptor e5 (31 kDa, Protein from Homo sapiens)
Cryo-EM structure of the 9-hydroxystearic acid bound GPR120-Gi complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8id3
Q-score: 0.522
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- 9-hydroxyoctadecanoic acid (300 Da, Ligand)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the 9-hydroxystearic acid bound gpr120-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the linoleic acid bound GPR120-Gi complex
Resolution: 3.1 Å
EM Method: Single-particle
Fitted PDBs: 8id4
Q-score: 0.547
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Cryo-em structure of the linoleic acid bound gpr120-gi complex (Complex from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
- Linoleic acid (280 Da, Ligand)
Cryo-EM structure of the oleic acid bound GPR120-Gi complex
Resolution: 2.8 Å
EM Method: Single-particle
Fitted PDBs: 8id6
Q-score: 0.532
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
- Oleic acid (282 Da, Ligand)
- Cryo-em structure of the oleic acid bound gpr120-gi complex (Complex from Homo sapiens)
Cryo-EM structure of the TUG891 bound GPR120-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8id8
Q-score: 0.524
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- 3-{4-[(4-fluoro-4'-methyl[1,1'-biphenyl]-2-yl)methoxy]phenyl}propanoic acid (364 Da, Ligand)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Cryo-em structure of the tug891 bound gpr120-gi complex (Complex from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)
Cryo-EM structure of the eicosapentaenoic acid bound GPR120-Gi complex
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8id9
Q-score: 0.538
Mao C, Xiao P, Tao XN, Qin J, He QT, Zhang C, Guo SC, Du YQ, Chen LN, Shen DD, Yang ZS, Zhang HQ, Huang SM, He YH, Cheng J, Zhong YN, Shang P, Chen J, Zhang DL, Wang QL, Liu MX, Li GY, Guo Y, Xu HE, Wang C, Zhang C, Feng S, Yu X, Zhang Y, Sun JP
Science (2023) 380 pp. eadd6220-eadd6220 [ Pubmed: 36862765 DOI: doi:10.1126/science.add6220 ]
- Guanine nucleotide-binding protein g(i) subunit alpha-1 (40 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(t) subunit beta-1 (37 kDa, Protein from Homo sapiens)
- Guanine nucleotide-binding protein g(i)/g(s)/g(o) subunit gamma-2 (7 kDa, Protein from Homo sapiens)
- Scfv16 (30 kDa, Protein from Homo sapiens)
- 5,8,11,14,17-eicosapentaenoic acid (302 Da, Ligand)
- Cryo-em structure of the eicosapentaenoic acid bound gpr120-gi complex (Complex from Homo sapiens)
- Free fatty acid receptor 4 (40 kDa, Protein from Homo sapiens)