Cryo-EM structure of the inhibitor-bound Vo complex from Enterococcus hirae
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 8wci
Q-score: 0.725
Suzuki K, Goto Y, Otomo A, Shimizu K, Abe S, Moriyama K, Yasuda S, Hashimoto Y, Kurushima J, Mikuriya S, Imai FL, Adachi N, Kawasaki M, Sato Y, Ogasawara S, Iwata I, Senda T, Ikeguchi M, Tomita H, Iino R, Moriya T, Murata T
To Be Published
- Cardiolipin (1 kDa, Ligand)
- Water (18 Da, Ligand)
- V-type sodium atpase subunit i (76 kDa, Protein from Enterococcus hirae ATCC 9790)
- N,n-dimethyl-4-(5-methyl-1h-benzimidazol-2-yl)aniline (251 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- V-type sodium atpase subunit k (16 kDa, Protein from Enterococcus hirae ATCC 9790)
- V-atpase (735 kDa, Complex from Enterococcus hirae ATCC 9790)
Cryo-EM Structure of inhibitor-free hERG Channel
Resolution: 3.27 Å
EM Method: Single-particle
Fitted PDBs: 8zyn
Q-score: 0.469
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
- Potassium channel (Complex from Homo sapiens)
- Potassium voltage-gated channel subfamily h member 2 (91 kDa, Protein from Homo sapiens)
Cryo-EM Structure of astemizole-bound hERG Channel
Resolution: 3.29 Å
EM Method: Single-particle
Fitted PDBs: 8zyo
Q-score: 0.479
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
Cryo-EM Structure of E-4031-bound hERG Channel
Resolution: 3.19 Å
EM Method: Single-particle
Fitted PDBs: 8zyp
Q-score: 0.503
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
Cryo-EM Structure of pimozide-bound hERG Channel
Resolution: 3.18 Å
EM Method: Single-particle
Fitted PDBs: 8zyq
Q-score: 0.488
Miyashita Y, Moriya T, Kato T, Kawasaki M, Yasuda S, Adachi N, Suzuki K, Ogasawara S, Saito T, Senda T, Murata T
Structure (2024) 32 pp. 1926- [ Pubmed: 39321803 DOI: doi:10.1016/j.str.2024.08.021 ]
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in LMNG detergent
Resolution: 2.49 Å
EM Method: Single-particle
Fitted PDBs: 8y6h
Q-score: 0.608
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
- Elacridar (563 Da, Ligand)
- Multidrug resistance protein (Complex from Homo sapiens)
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
Resolution: 2.54 Å
EM Method: Single-particle
Fitted PDBs: 8y6i
Q-score: 0.576
Hamaguchi-Suzuki N, Adachi N, Moriya T, Yasuda S, Kawasaki M, Suzuki K, Ogasawara S, Anzai N, Senda T, Murata T
Biochem Biophys Res Commun (2024) 709 pp. 149855-149855 [ DOI: doi:10.1016/j.bbrc.2024.149855 Pubmed: 38579618 ]
- Uic2 fab heavy chain (24 kDa, Protein from Mus musculus)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Elacridar (563 Da, Ligand)
- Multidrug resistance protein (Complex from Homo sapiens)
- Cholesterol (386 Da, Ligand)
- Atp-dependent translocase abcb1,mneongreen (170 kDa, Protein from Homo sapiens)
- Uic2 fab light chain (24 kDa, Protein from Mus musculus)
Anzai I, Fujita J, Ono C, Kosaka Y, Miyamoto Y, Shichinohe S, Takada K, Torii S, Taguwa S, Suzuki K, Makino F, Kajita T, Inoue T, Namba K, Watanabe T, Matsuura Y
To Be Published
- Neutralizing antibody csw1-1805 heavy chain (Protein from Mus musculus)
- Spike protein (Complex from Mus musculus)
- Neutralizing antibody csw1-1805 light chain (Protein from Mus musculus)
- Antibody (Complex)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
- Cryo-em structure of the sars-cov-2 spike protein (3-up rbd) bound to neutralizing antibody csw1-1805 (Complex from Severe acute respiratory syndrome coronavirus 2)
Anzai I, Fujita J, Ono C, Kosaka Y, Miyamoto Y, Shichinohe S, Takada K, Torii S, Taguwa S, Suzuki K, Makino F, Kajita T, Inoue T, Namba K, Watanabe T, Matsuura Y
To Be Published
- Cryo-em structure of the sars-cov-2 spike protein (1-up rbd) bound to neutralizing antibody csw2-1353 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody csw2-1353 heavy chain (Protein from Mus musculus)
- Spike protein (Complex from Mus musculus)
- Neutralizing antibody csw2-1353 light chain (Protein from Mus musculus)
- Antibody (Complex)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)
Anzai I, Fujita J, Ono C, Kosaka Y, Miyamoto Y, Shichinohe S, Takada K, Torii S, Taguwa S, Suzuki K, Makino F, Kajita T, Inoue T, Namba K, Watanabe T, Matsuura Y
To Be Published
- Neutralizing antibody csw2-1353 heavy chain (Protein from Mus musculus)
- Spike protein (Complex from Mus musculus)
- Cryo-em structure of the sars-cov-2 spike protein (2-up rbd) bound to neutralizing antibody csw2-1353 (Complex from Severe acute respiratory syndrome coronavirus 2)
- Neutralizing antibody csw2-1353 light chain (Protein from Mus musculus)
- Antibody (Complex)
- Spike glycoprotein (Protein from Severe acute respiratory syndrome coronavirus 2)