Resolution: 2.75 Å
EM Method: Single-particle
Fitted PDBs: 8wgr
Q-score: 0.576
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Water (18 Da, Ligand)
- Potassium ion (39 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 3-(10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n-methylpropan-1-amine (266 Da, Ligand)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 8wgx
Q-score: 0.462
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- L-norepinephrine (169 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 8z1l
Q-score: 0.451
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- (3r)-n-methyl-3-(2-methylphenoxy)-3-phenyl-propan-1-amine (255 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
Resolution: 2.85 Å
EM Method: Single-particle
Fitted PDBs: 8i3v
Q-score: 0.57
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Water (18 Da, Ligand)
- (1s)-1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile (324 Da, Ligand)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- Net (Complex from Homo sapiens)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8hfe
Q-score: 0.629
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Water (18 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
Resolution: 2.86 Å
EM Method: Single-particle
Fitted PDBs: 8hff
Q-score: 0.537
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- L-norepinephrine (169 Da, Ligand)
- Water (18 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hfg
Q-score: 0.442
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Water (18 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- L-dopamine (153 Da, Ligand)
Resolution: 2.5 Å
EM Method: Single-particle
Fitted PDBs: 8hfi
Q-score: 0.644
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Water (18 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 3-(10,11-dihydro-5h-dibenzo[b,f]azepin-5-yl)-n-methylpropan-1-amine (266 Da, Ligand)
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 8hfl
Q-score: 0.556
Tan J, Xiao Y, Kong F, Zhang X, Xu H, Zhu A, Liu Y, Lei J, Tian B, Yuan Y, Yan C
Nature (2024) 632 pp. 921-929 [ DOI: doi:10.1038/s41586-024-07719-z Pubmed: 39048818 ]
- Water (18 Da, Ligand)
- Bupropion (239 Da, Ligand)
- Net (110 kDa, Complex from Homo sapiens)
- Sodium-dependent noradrenaline transporter (69 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
Cryo-EM structure of a Legionella effector complexed with actin and AMP
Resolution: 2.66 Å
EM Method: Single-particle
Fitted PDBs: 8jo3
Q-score: 0.618
Wang T, Song X, Tan J, Xian W, Zhou X, Yu M, Wang X, Xu Y, Wu T, Yuan K, Ran Y, Yang B, Fan G, Liu X, Zhou Y, Zhu Y
Nature (2024) 631 pp. 393-401 [ DOI: doi:10.1038/s41586-024-07573-z Pubmed: 38776962 ]
- Substrate of the dot/icm secretion system (50 kDa, Protein from Legionella sainthelensi)
- Adenosine monophosphate (347 Da, Ligand)
- Adenosine-5'-triphosphate (507 Da, Ligand)
- Actin, alpha skeletal muscle (42 kDa, Protein from Oryctolagus cuniculus)
- Calcium ion (40 Da, Ligand)
- Cryo-em structure of a legionella effector complexed with actin and amp (Complex from Legionella sainthelensi)