Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state
Resolution: 2.2 Å
EM Method: Single-particle
Fitted PDBs: 7y7v
Q-score: 0.681
Zhu A, Huang J, Kong F, Tan J, Lei J, Yuan Y, Yan C
Nat Struct Mol Biol (2023) 30 pp. 1012-1022 [ DOI: doi:10.1038/s41594-023-00983-z Pubmed: 37400655 ]
- Water (18 Da, Ligand)
- Gat1 (110 kDa, Complex from Homo sapiens)
- Sodium- and chloride-dependent gaba transporter 1 (70 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7y7w
Q-score: 0.652
Zhu A, Huang J, Kong F, Tan J, Lei J, Yuan Y, Yan C
Nat Struct Mol Biol (2023) 30 pp. 1012-1022 [ DOI: doi:10.1038/s41594-023-00983-z Pubmed: 37400655 ]
- Gat1 (110 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium- and chloride-dependent gaba transporter 1 (70 kDa, Protein from Homo sapiens)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- Gamma-amino-butanoic acid (103 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 2.4 Å
EM Method: Single-particle
Fitted PDBs: 7y7y
Q-score: 0.671
Zhu A, Huang J, Kong F, Tan J, Lei J, Yuan Y, Yan C
Nat Struct Mol Biol (2023) 30 pp. 1012-1022 [ DOI: doi:10.1038/s41594-023-00983-z Pubmed: 37400655 ]
- Gat1 (110 kDa, Complex from Homo sapiens)
- Water (18 Da, Ligand)
- Sodium- and chloride-dependent gaba transporter 1 (70 kDa, Protein from Homo sapiens)
- (3r)-piperidine-3-carboxylic acid (129 Da, Ligand)
- Sodium ion (22 Da, Ligand)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.2 Å
EM Method: Single-particle
Fitted PDBs: 7y7z
Q-score: 0.532
Zhu A, Huang J, Kong F, Tan J, Lei J, Yuan Y, Yan C
Nat Struct Mol Biol (2023) 30 pp. 1012-1022 [ DOI: doi:10.1038/s41594-023-00983-z Pubmed: 37400655 ]
- Gat1 (110 kDa, Complex from Homo sapiens)
- Tiagabine (375 Da, Ligand)
- Sodium- and chloride-dependent gaba transporter 1 (70 kDa, Protein from Homo sapiens)
- Chloride ion (35 Da, Ligand)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Resolution: 3.35 Å
EM Method: Single-particle
Fitted PDBs: 7wm0
Q-score: 0.295
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ DOI: doi:10.1016/j.chom.2022.03.035 ]
- Heavy chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Light chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (state2) (Complex from Severe acute respiratory syndrome coronavirus 2)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down- and 2 up RBDs)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7wly
Q-score: 0.36
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ Pubmed: 35436443 DOI: doi:10.1016/j.chom.2022.03.035 ]
- Heavy chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)
Cryo-EM structure of the Omicron S in complex with 35B5 Fab(1 down-, 1 up- and 1 invisible RBDs)
Resolution: 2.98 Å
EM Method: Single-particle
Fitted PDBs: 7wlz
Q-score: 0.395
Wang X, Chen X, Tan J, Yue S, Zhou R, Xu Y, Lin Y, Yang Y, Zhou Y, Deng K, Chen Z, Ye L, Zhu Y
Cell Host Microbe (2022) 30 pp. 887- [ Pubmed: 35436443 DOI: doi:10.1016/j.chom.2022.03.035 ]
- Heavy chain of 35b5 fab (25 kDa, Protein from Homo sapiens)
- Complex of sars-cov-2 spike glycoprotein and 35b5 fab (Complex from Severe acute respiratory syndrome coronavirus 2)
- Light chain of 35b5 fab (23 kDa, Protein from Homo sapiens)
- Sars-cov-2 spike glycoprotein (Complex from Homo sapiens)
- 35b5 fab (Complex)
- Spike glycoprotein (142 kDa, Protein from Severe acute respiratory syndrome coronavirus 2)
- 2-acetamido-2-deoxy-beta-d-glucopyranose (221 Da, Ligand)