Insulin Degrading Enzyme pO/pC
Resolution: 3.3 Å
EM Method: Single-particle
Fitted PDBs: 7rze
Q-score: 0.47
Mancl JM, Liang WG, Wei H, Carragher B, Potter CS, Tang WJ
To Be Published
- Cysteine-free insulin-degrading enzyme (Complex from Homo sapiens)
- Insulin a chain, insulin b chain (Complex from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme (117 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme in complex with insulin a chain and insulin b chain (Complex)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 7rzf
Q-score: 0.417
Mancl JM, Liang WG, Wei H, Carragher B, Potter CS, Tang WJ
To Be Published
- Cysteine-free insulin-degrading enzyme (Complex from Homo sapiens)
- Insulin a chain, insulin b chain (Complex from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme (117 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme in complex with insulin a chain and insulin b chain (Complex)
Resolution: 4.1 Å
EM Method: Single-particle
Fitted PDBs: 7rzg
Q-score: 0.329
Resolution: 3.8 Å
EM Method: Single-particle
Fitted PDBs: 7rzh
Q-score: 0.234
Insulin Degrading Enzyme pC/pC
Resolution: 3.0 Å
EM Method: Single-particle
Fitted PDBs: 7rzi
Q-score: 0.54
Mancl JM, Liang WG, Wei H, Carragher B, Potter CS, Tang WJ
To Be Published
- Cysteine-free insulin-degrading enzyme (Complex from Homo sapiens)
- Insulin a chain, insulin b chain (Complex from Homo sapiens)
- Insulin a chain (2 kDa, Protein from Homo sapiens)
- Insulin b chain (3 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme (117 kDa, Protein from Homo sapiens)
- Cysteine-free insulin-degrading enzyme in complex with insulin a chain and insulin b chain (Complex)
CryoEM of PreP prepared via Chameleon
Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Nat Commun (2022) 13 [ DOI: 10.1038/s41467-022-29322-4 Pubmed: 35383169 ]
Image sets:
- Apo-PreP micrographs
- Amyloid beta bound PreP
- Citrate synthase presequence bound PreP
- PreP half particles
CryoET of presequence protease single particle
Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Nat Commun (2022) 13 [ DOI: 10.1038/s41467-022-29322-4 Pubmed: 35383169 ]
Image sets:
CryoET of presequence protease single particle
Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Nat Commun (2022) 13 pp. 1833-1833 [ DOI: doi:10.1038/s41467-022-29322-4 Pubmed: 35383169 ]
- Human presequence protease (117 kDa, Complex from Escherichia phage EcSzw-2)
CryoEM structure of human presequence protease in partial open state 1
Resolution: 3.7 Å
EM Method: Single-particle
Fitted PDBs: 6xos
Q-score: 0.405
Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Nat Commun (2022) 13 pp. 1833-1833 [ DOI: doi:10.1038/s41467-022-29322-4 Pubmed: 35383169 ]
CryoEM structure of human presequence protease in partial open state 2
Resolution: 3.9 Å
EM Method: Single-particle
Fitted PDBs: 6xot
Q-score: 0.315
Liang WG, Wijaya J, Wei H, Noble AJ, Mancl JM, Mo S, Lee D, Lin King JV, Pan M, Liu C, Koehler CM, Zhao M, Potter CS, Carragher B, Li S, Tang WJ
Nat Commun (2022) 13 pp. 1833-1833 [ DOI: doi:10.1038/s41467-022-29322-4 Pubmed: 35383169 ]