Structure of human HCN4 hyperpolarization-activated cyclic nucleotide-gated ion channel
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyn
Q-score: 0.479
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
Resolution: 3.4 Å
EM Method: Single-particle
Fitted PDBs: 6gyo
Q-score: 0.502
Shintre CA, Pike ACW, Tessitore A, Young M, Bushell SR, Strain-Damerell C, Mukhopadhyay S, Burgess-Brown NA, Huiskonen JT, Arrowsmith CH, Edwards AM, Bountra C, Carpenter EP
To Be Published
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ion channel 4 (Cellular component from Homo sapiens)
- 1,2-distearoyl-sn-glycerophosphoethanolamine (748 Da, Ligand)
- Adenosine-3',5'-cyclic-monophosphate (329 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 (60 kDa, Protein from Homo sapiens)
- 1,2-diacyl-sn-glycero-3-phosphoinositol (836 Da, Ligand)
- Unknown atom or ion (65 Da, Ligand)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form)
Resolution: 3.47 Å
EM Method: Single-particle
Fitted PDBs: 6r7x
Q-score: 0.516
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ DOI: doi:10.1038/s41467-019-11753-1 Pubmed: 31477691 ]
- Calcium ion (40 Da, Ligand)
- Undecyl-maltoside (496 Da, Ligand)
- 1,2-diacyl-sn-glycero-3-phosphocholine (790 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (low Ca2+, closed form)
Resolution: 4.2 Å
EM Method: Single-particle
Fitted PDBs: 6r7y
Q-score: 0.417
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ DOI: doi:10.1038/s41467-019-11753-1 Pubmed: 31477691 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Calcium ion (40 Da, Ligand)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)
CryoEM structure of calcium-free human TMEM16K / Anoctamin 10 in detergent (closed form)
Resolution: 5.14 Å
EM Method: Single-particle
Fitted PDBs: 6r7z
Q-score: 0.269
Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, Love JD, Burgess-Brown NA, Sitsapesan R, Stansfeld PJ, Huiskonen JT, Tammaro P, Accardi A, Carpenter EP
Nat Commun (2019) 10 pp. 3956-3956 [ DOI: doi:10.1038/s41467-019-11753-1 Pubmed: 31477691 ]
- Anoctamin 10 (153 kDa, Cellular component from Homo sapiens)
- Anoctamin-10 (77 kDa, Protein from Homo sapiens)